Analysis Tools
cardiovascular system
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• in females
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• females but not males show a significant increase in systolic blood pressure compared to sex-matched controls
• difference in females is seen when mice are on a high or low salt diet
• estrogen supplementation reduces systolic blood pressures in females to normal levels
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• vasoconstriction in response to angiotensin II and endothelin I is enhanced in arterioles from females but not in those from males
• for both males and females baseline arteriole diameters are similar to controls
• supplementation with estrogen attenuates arteriole responses to angiotensin II in females but not in wild -type controls
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homeostasis/metabolism
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• decrease in 17beta-estradiol levels in females compared to female littermate controls
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renal/urinary system
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• despite loss of expression in the kidneys, assays of gross kidney function (urine osmolality, serum creatinine, urine output) are normal
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• increase in proximal tubular transport rates in females but not in males
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reproductive system
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• when females are continuously mated to wild-type males litter sizes are significantly smaller compared to crosses of wild-type females to wild-type males
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muscle
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• vasoconstriction in response to angiotensin II and endothelin I is enhanced in arterioles from females but not in those from males
• for both males and females baseline arteriole diameters are similar to controls
• supplementation with estrogen attenuates arteriole responses to angiotensin II in females but not in wild -type controls
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