Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plvaptm1.1Rvst mutation
(1 available);
any
Plvap mutation
(47 available)
Tg(Cdh5-cre)1Spe mutation
(2 available)
|
|
|
mortality/aging
|
• Background Sensitivity: display 100% lethality by P2 on a congenic C57BL/6 background unlike mice on a mixed background where about 20-30% of mice survive to 6-7 months of age
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm3Spe mutation
(0 available);
any
Runx1 mutation
(35 available)
Tg(Cdh5-cre)1Spe mutation
(2 available)
|
|
|
mortality/aging
|
• 65% of embryos die between E12.5 and E15.5
|
hematopoietic system
|
• 10% of E12.5 embryos have a pale liver due to anemia
|
|
• hematopoietic stem cell first derive as clusters of Kithigh cells from the endothelium of dorsal aorta and vitelline and umbilical arteries of E10.5 conceptus
• these clusters are absent in mutant E10.5 conceptus and there is a 90-fold decrease in the Kithigh cells
|
|
• there is about a 8-fold decrease in CFUs from the yolk sac, vitelline and umbilical arteries, placenta and fetal liver
• over 99% of the CFUs that do develop in culture have one functional Runx1 allele
• decreased hematopoietic stem cell numbers are reflected in poor engraftment of mutant bone marrow cells into irradiated recipients
• CFUs cultured from bone marrow of transplant recipients are much reduced compared to controls and over 99% also have one functional Runx1 allele
|
cardiovascular system
|
• 10% of E12.5 embryos have hemorrhaging within the central nervous system
|
liver/biliary system
|
• 10% of E12.5 embryos have a pale liver due to anemia
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plvaptm1.1Rvst mutation
(1 available);
any
Plvap mutation
(47 available)
Tg(Cdh5-cre)1Spe mutation
(2 available)
|
|
|
mortality/aging
|
• Background Sensitivity: display 100% lethality by P2 on a congenic C57BL/6 background unlike mice on a mixed background where about 20-30% of mice survive to 6-7 months of age
|
cardiovascular system
|
• lack diaphragms in endothelial fenestrae, transendothelial channels, and caveolae in pancreas, intestine, kidney, lung and adrenals
|
|
• leakage of Evans Blue dye is dramatically increased in organs with fenestrated endothelial cells
• leakage of Evans Blue dye is highest in the intestine
|
homeostasis/metabolism
growth/size/body
|
• due to accumulation of ascites
|
adipose tissue
endocrine/exocrine glands
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Best3tm1.1Zhoj mutation
(0 available);
any
Best3 mutation
(37 available)
Tg(Cdh5-cre)1Spe mutation
(2 available)
|
|
|
cardiovascular system
N |
• no effect on development of aortic dissections or change in blood pressure
|