Phenotypes associated with this allele

• Allele Symbol: C2cd3^{Gt(AG0177)Wtsi}
• Allele Name: gene trap AG0177, Wellcome Trust Sanger Institute
• Allele ID: MGI:3836403
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	C2cd3^Gt(AG0177)Wtsi/C2cd3^Gt(AG0177)Wtsi	involves: 129P2/OlaHsd * C3H/He	MGI:3836405
ht2	C2cd3^hty/C2cd3^Gt(AG0177)Wtsi	involves: 129P2/OlaHsd * C3H/He * C57BL/6	MGI:3836406

Genotype
MGI:3836405

hm1

• Allelic Composition: C2cd3^{Gt(AG0177)Wtsi}/C2cd3^{Gt(AG0177)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C3H/He

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:142506 )

• disrupt embryonic development and caused embryonic lethality between E10.5 and E11.5

• overall phenotype is similar but more severe defects in embryonic development than homozygous C2cd3^hty

nervous system

abnormal floor plate morphology ( J:142506 )

• the basal plates of the midbrain are flat in homozygous mutants with exencephaly

exencephaly ( J:142506 )

• some homozygous mutants exhibit exencephaly in the midbrain and posterior forebrain

embryo

absent embryonic cilia ( J:142506 )

• primary cilia were absent in nearly all cells of the ventral embryonic node

abnormal dorsal-ventral axis patterning ( J:142506 )

• dorsal-ventral patterning of the CNS is disrupted

• loss of ventral cell types in the spinal cord and a ventral expansion of more lateral cell types

• more severe loss of ventral cell types than homozygous C2cd3^hty

abnormal floor plate morphology ( J:142506 )

• the basal plates of the midbrain are flat in homozygous mutants with exencephaly

cellular

absent embryonic cilia ( J:142506 )

• primary cilia were absent in nearly all cells of the ventral embryonic node

Genotype
MGI:3836406

ht2

• Allelic Composition: C2cd3^hty/C2cd3^{Gt(AG0177)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C3H/He * C57BL/6

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:142506 )

• disrupt embryonic development and caused embryonic lethality between E10.5 and E13.5

• overall phenotype is similar to homozygous C2cd3^hty

embryo

abnormal rostral-caudal body axis extension ( J:142506 )

• twisted body axis

cardiovascular system

pericardial edema ( J:142506 )

homeostasis/metabolism

pericardial edema ( J:142506 )