Phenotypes associated with this allele

• Allele Symbol: Gtf2ird1^tm1Lro
• Allele Name: targeted mutation 1, L R Osborne
• Allele ID: MGI:3835413
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gtf2ird1^tm1Lro/Gtf2ird1^tm1Lro	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3835420

Genotype
MGI:3835420

hm1

• Allelic Composition: Gtf2ird1^tm1Lro/Gtf2ird1^tm1Lro
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:145599 )

• reduced body size in both sexes

behavior/neurological

abnormal cued conditioning behavior ( J:145599 )

• cued fear conditioning is reduced, less freezing, relative to controls

decreased aggression towards mice ( J:145599 )

• reduced aggression

• fewer aggressive interactions of shorter duration

• increased tendancy to follow after intruder mice and followed for longer times

decreased anxiety-related response ( J:145599 )

• reduced anxiety in an elevated maze

• increased time in the center of an open field

decreased fear-related response ( J:145599 )

• contextual fear conditioning is normal

• cued fear conditioning is reduced, less freezing, relative to controls

homeostasis/metabolism

abnormal serotonin level ( J:145599 )

• metabolite 5-hydroxyindolacetic acid levels are elevated in the amygdala, frontal cortex, and parietal cortex