About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pirttm1Xzd
targeted mutation 1, Xinzhong Dong
MGI:3834636
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pirttm1Xzd/Pirttm1Xzd B6.129-Pirt1tm1Xzd MGI:3834639


Genotype
MGI:3834639
hm1
Allelic
Composition
Pirttm1Xzd/Pirttm1Xzd
Genetic
Background
B6.129-Pirt1tm1Xzd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pirttm1Xzd mutation (0 available); any Pirt mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• using capsaicin but not mustard oil regardless of inflammatory state
• at 48, 50, and 52.5 degrees Celsius using a tail immersion test and at 50 and 52.5 degrees Celsius using a hot plate test

nervous system
• dorsal root ganglion nerves responding to noxious heat and capsaicin exhibit a smaller response than in wild-type mice with reduced current over capacitance values
• bradykinin-mediated TRPV1 potentiation is reduced compared to in wild-type mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
05/07/2024
MGI 6.23
The Jackson Laboratory