Phenotypes associated with this allele

• Allele Symbol: Kdm1a^tm1.2Tche
• Allele Name: targeted mutation 1.2, Taiping Chen
• Allele ID: MGI:3834630
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kdm1a^tm1.2Tche/Kdm1a^tm1.2Tche	involves: 129 * C57BL/6	MGI:3834631
ht2	Kdm1a^tm1.2Tche/Kdm1a^+	involves: 129 * C57BL/6	MGI:7544995
ht3	Kdm1a^tm1.1Tche/Kdm1a^tm1.2Tche	Not Specified	MGI:7544999

Genotype
MGI:3834631

hm1

• Allelic Composition: Kdm1a^tm1.2Tche/Kdm1a^tm1.2Tche
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:144527 )

• all mice are resorbed by E7.5

embryo

failure to gastrulate ( J:144527 )

embryonic growth arrest ( J:144527 )

• development arrests at or before E5.5 with the egg cylinder failing to elongate and undergo gastrulation

absent egg cylinders ( J:144527 )

cellular

increased apoptosis ( J:144527 )

• in cultured cells

Genotype
MGI:7544995

ht2

• Allelic Composition: Kdm1a^tm1.2Tche/Kdm1a⁺
• Genetic Background: involves: 129 * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:144527 )

• mice are viable, fertile and exhibit no obvious phenotype

Genotype
MGI:7544999

ht3

• Allelic Composition: Kdm1a^tm1.1Tche/Kdm1a^tm1.2Tche
• Genetic Background: Not Specified

cardiovascular system

ventricular septal defect ( J:270116 )

• at E18.5, all (4 of 4) mice showed VSDs