Phenotypes associated with this allele

• Allele Symbol: Lpp^tm1Wjmv
• Allele Name: targeted mutation 1, Wim JM Van de Ven
• Allele ID: MGI:3834596
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lpp^tm1Wjmv/Lpp^tm1Wjmv	B6.129P2-Lpp^tm1Wjmv	MGI:3834600
hm2	Lpp^tm1Wjmv/Lpp^tm1Wjmv	involves: 129P2/OlaHsd * Swiss	MGI:3834599

Genotype
MGI:3834600

hm1

• Allelic Composition: Lpp^tm1Wjmv/Lpp^tm1Wjmv
• Genetic Background: B6.129P2-Lpp^tm1Wjmv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:144517 )

• Background Sensitivity: slight deficiency of homozygotes at birth, particularly of females (17% vs 25%)

• no additional lethality after birth

reproductive system

reproductive system phenotype ( J:144517 )

N • male reproductive system and fertility are normal

reduced female fertility ( J:144517 )

♀ • crosses of homozygotes result in 46% fewer offspring

♀ • high levels of embryo death and resorption or necrosis observed at various time points from E11.5 to E15.5

♀ • survival of pups after birth reduced to about 50%

homeostasis/metabolism

impaired wound healing ( J:144517 )

• MEFs show a 50% reduction of migration into wounds 24 hours after injury

cellular

abnormal cell death ( J:144517 )

• MEFs die faster than normal

Genotype
MGI:3834599

hm2

• Allelic Composition: Lpp^tm1Wjmv/Lpp^tm1Wjmv
• Genetic Background: involves: 129P2/OlaHsd * Swiss

mortality/aging

mortality/aging ( J:144517 )

N • Background Sensitivity: mice born at a normal Mendelian ratio