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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rab27btm1Tiz
targeted mutation 1, Tetsuro Izumi
MGI:3834149
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rab27btm1Tiz/Rab27btm1Tiz involves: 129P2/OlaHsd * C3H/He MGI:3834159
cx2
 		Rab27aash/Rab27aash
Rab27btm1Tiz/Rab27btm1Tiz 		involves: 129P2/OlaHsd * C3H/He * C3H/HeSn MGI:3834158


Genotype
MGI:3834159
hm1
Allelic
Composition		 Rab27btm1Tiz/Rab27btm1Tiz
Genetic
Background		 involves: 129P2/OlaHsd * C3H/He
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab27btm1Tiz mutation (1 available); any Rab27b mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:145238 )
• mice exhibit no apparent abnormalities in general appearance or behavior




Genotype
MGI:3834158
cx2
Allelic
Composition		 Rab27aash/Rab27aash
Rab27btm1Tiz/Rab27btm1Tiz
Genetic
Background		 involves: 129P2/OlaHsd * C3H/He * C3H/HeSn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab27aash mutation (3 available); any Rab27a mutation (147 available)
Rab27btm1Tiz mutation (1 available); any Rab27b mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal reproductive system physiology ( J:145238 )
• mice exhibit minor defects in reproduction

endocrine/exocrine glands
abnormal corticotroph morphology ( J:145238 )
• ACTH-containing granules are not polarized to the plasma membrane as in wild-type cells
• however, evoked ACTH secretion is normal

nervous system
abnormal corticotroph morphology ( J:145238 )
• ACTH-containing granules are not polarized to the plasma membrane as in wild-type cells
• however, evoked ACTH secretion is normal

pigmentation

integument




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory