Analysis Tools
growth/size/body
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• reduced body weight compared to controls throughout life
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• marked reduction in weight gain after birth
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• when fed a high fat diet
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muscle
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• muscle triglyceride levels are decreased compared to controls when fed a high fat diet
• muscle triglyceride levels are similar to controls on a normal diet but
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cellular
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• enhanced glucose uptake in brown adipose tissue in vivo but not in isolated primary adipocytes from brown adipose tissue
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behavior/neurological
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• significant increase in food intake normalized to body weight
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• slight increase in locomotor activity that is more apparent in the dark phase
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adipose tissue
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• in mice fed a high fat diet but not in mice fed a normal diet
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• marked reduction in cell size in both white and brown adipose tissue
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• reduction in the mass of epididymal white adipose tissue on a normal or high fat diet compared to diet matched controls
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• enhanced glucose uptake in brown adipose tissue in vivo but not in isolated primary adipocytes from brown adipose tissue
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homeostasis/metabolism
| N |
• despite the increase in metabolic rate, no difference in body temperature compared to controls is detected and no defect in adaptive thermogenesis is seen
• unlike metabolic rate, respiratory quotient in mice fed a high fat diet is similar to diet matched controls
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• when fed a high fat diet
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• on a standard or high fat diet
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• on a standard diet
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• on a standard or high fat diet
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• on a standard diet
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• on a standard diet
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• on a standard diet
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• on a standard diet
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• reduction in liver triglyceride levels on a normal or high fat diet compared to diet matched controls
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• muscle triglyceride levels are decreased compared to controls when fed a high fat diet
• muscle triglyceride levels are similar to controls on a normal diet but
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• enhanced metabolic rate in both dark and light phases
• metabolic rate is also increased when fed a high fat diet compared to diet matched controls
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liver/biliary system
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• reduction in liver triglyceride levels on a normal or high fat diet compared to diet matched controls
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• resistance to high fat diet induce hepatic steatosis
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digestive/alimentary system
| N |
• assays indicate nutrient absorption is not significantly different from controls
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integument
