All Phenotypes Dab1<tm6Cpr> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dab1^tm6Cpr
targeted mutation 6, Jonathan A Cooper
MGI:3833830

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dab1^tm6Cpr/Dab1^tm6Cpr	involves: 129S4/SvJaeSor * C57BL/6	MGI:3833855
ht2	Dab1^tm5Cpr/Dab1^tm6Cpr	involves: 129S4/SvJaeSor * C57BL/6	MGI:3833854
ht3	Dab1^tm1Cpr/Dab1^tm6Cpr	involves: 129S4/SvJaeSor * C57BL/6	MGI:3833856

Allelic Composition	Dab1^tm6Cpr/Dab1^tm6Cpr
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1^tm6Cpr mutation (0 available); any Dab1 mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal telencephalon development ( J:145031 )

abnormal cortical marginal zone morphology ( J:145031 )

• absent

abnormal subplate morphology ( J:145031 )

• poorly developed at E16.5

abnormal hippocampus morphology ( J:145031 )

• disorganized

abnormal cerebral cortex morphology ( J:145031 )

• disorganized

abnormal stratification in cerebral cortex ( J:145031 )

• disrupted order of neocortical layers

abnormal cerebellum morphology ( J:145031 )

ectopic Purkinje cell ( J:145031 )

• about 1/3 of cells are positioned normally above the internal granule layer, while others remain in or below the internal granule layer

small cerebellum ( J:145031 )

Allelic Composition	Dab1^tm5Cpr/Dab1^tm6Cpr
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1^tm5Cpr mutation (0 available); any Dab1 mutation (78 available)
Dab1^tm6Cpr mutation (0 available); any Dab1 mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:145031 )

N	• mutant animals are viable with no obvious abnormalities • mutant animals have a well developed cortical marginal zone, normal hippocampus, and a cerebellum of normal size and foliation pattern

Allelic Composition	Dab1^tm1Cpr/Dab1^tm6Cpr
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1^tm1Cpr mutation (1 available); any Dab1 mutation (78 available)
Dab1^tm6Cpr mutation (0 available); any Dab1 mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cortical marginal zone morphology ( J:145031 )

• absent

abnormal stratification in cerebral cortex ( J:145031 )

• disrupted order of neocortical layers

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24