Phenotypes associated with this allele

• Allele Symbol: Dab1^tm5Cpr
• Allele Name: targeted mutation 5, Jonathan A Cooper
• Allele ID: MGI:3833827
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dab1^tm5Cpr/Dab1^tm5Cpr	involves: 129S4/SvJaeSor * C57BL/6	MGI:3833853
ht2	Dab1^tm5Cpr/Dab1^tm6Cpr	involves: 129S4/SvJaeSor * C57BL/6	MGI:3833854

Genotype
MGI:3833853

hm1

• Allelic Composition: Dab1^tm5Cpr/Dab1^tm5Cpr
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal telencephalon development ( J:145031 )

abnormal cortical marginal zone morphology ( J:145031 )

• absent

abnormal subplate morphology ( J:145031 )

• poorly developed at E16.5

abnormal hippocampus morphology ( J:145031 )

• disorganized

abnormal cerebral cortex morphology ( J:145031 )

• disorganized

abnormal stratification in cerebral cortex ( J:145031 )

• inverted order of neocortical layers

abnormal cerebellum morphology ( J:145031 )

ectopic Purkinje cell ( J:145031 )

• about 1/3 of cells are positioned normally above the internal granule layer, while others remain in or below the internal granule layer

small cerebellum ( J:145031 )

Genotype
MGI:3833854

ht2

• Allelic Composition: Dab1^tm5Cpr/Dab1^tm6Cpr
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

nervous system

nervous system phenotype ( J:145031 )

N • mutant animals are viable with no obvious abnormalities

N • mutant animals have a well developed cortical marginal zone, normal hippocampus, and a cerebellum of normal size and foliation pattern