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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm1(Tcfe2a/Tal1)Xhsu
targeted mutation 1, Xiao-Hong Sun
MGI:3833549
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sortm1(Tcfe2a/Tal1)Xhsu involves: 129/Sv * C57BL/6 MGI:3833565


Genotype
MGI:3833565
cn1
Allelic
Composition
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sortm1(Tcfe2a/Tal1)Xhsu
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Thl mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Gt(ROSA)26Sortm1(Tcfe2a/Tal1)Xhsu mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• lin - kit+ Sca-1+ progenitor cells isolated from the bone marrow of mice treated with tamoxifen produce 20- to 40- fold more B cells than controls when cultured under condition supporting lymphopoiesis
• lin- kit+ Sca-1+ progenitor cells isolated from the bone marrow of mice treated with tamoxifen produce 10-fold lower percentages and numbers of myeloid lineage cells in vitro than controls
• however, normal number of myeloid cells are produced from myeloid progenitor cells

immune system
• lin - kit+ Sca-1+ progenitor cells isolated from the bone marrow of mice treated with tamoxifen produce 20- to 40- fold more B cells than controls when cultured under condition supporting lymphopoiesis
• lin- kit+ Sca-1+ progenitor cells isolated from the bone marrow of mice treated with tamoxifen produce 10-fold lower percentages and numbers of myeloid lineage cells in vitro than controls
• however, normal number of myeloid cells are produced from myeloid progenitor cells





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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory