Phenotypes associated with this allele

• Allele Symbol: Uhmk1^tm1Enbl
• Allele Name: targeted mutation 1, Elizabeth G Nabel
• Allele ID: MGI:3832867
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Uhmk1^tm1Enbl/Uhmk1^tm1Enbl	involves: 129/Sv * C57BL/6	MGI:3832889

Genotype
MGI:3832889

hm1

• Allelic Composition: Uhmk1^tm1Enbl/Uhmk1^tm1Enbl
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal vascular wound healing ( J:144737 )

• accelerated development of neointima after femoral artery wire injury

• apparent after 7 days

• no indication of increased cell proliferation

• increased numbers of vascular smooth muscle cells on luminal surface 5 days after injury

• T cells but not macrophage or neutrophiles recruited to injury site

homeostasis/metabolism

abnormal vascular wound healing ( J:144737 )

• accelerated development of neointima after femoral artery wire injury

• apparent after 7 days

• no indication of increased cell proliferation

• increased numbers of vascular smooth muscle cells on luminal surface 5 days after injury

• T cells but not macrophage or neutrophiles recruited to injury site

increased circulating cholesterol level ( J:144737 )

cellular

abnormal cell cycle ( J:144737 )

• reduced growth rate

• vascular smooth muscle cells show a delayed entry into S phase

abnormal cell migration ( J:144737 )

• vascular smooth muscle cells have a faster migration rate toward a serum gradient than controls in a transwell test system