Phenotypes associated with this allele

• Allele Symbol: Senp2^tm1Whsu
• Allele Name: targeted mutation 1, Wei Hsu
• Allele ID: MGI:3832730
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Senp2^tm1Whsu/Senp2^tm1Whsu	involves: 129S6/SvEvTac * C57BL/6	MGI:3832806

Genotype
MGI:3832806

hm1

• Allelic Composition: Senp2^tm1Whsu/Senp2^tm1Whsu
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:144707 )

• embryos die at E11.5 due to placental deficiencies

embryo

small placenta ( J:144707 )

• at E10.5, placenta has a mean diameter of 3.8 mm compared to 5.2 mm in controls

abnormal trophoblast layer morphology ( J:144707 )

• at E8.5, there is a reduction in the trophoblast giant cell layer (TGC)

• by E10.5, the thickness of all three trophoblast layers is severely reduced with the TGC layer almost completely absent

• cells within the trophoblast layer have defects in cell cycle progression with reduced proliferation rates at E7.5 and E8.5

• cells within the trophoblast layer have a defect in the G-to-S transition

• these cells are also defective in endoreduplication cell cycles that are necessary for proper differentiation

abnormal trophoblast giant cell morphology ( J:144707 )

• primary trophoblast giant cells are completely absent by E9.5

absent trophoblast giant cells ( J:144707 )

• primary trophoblast giant cells are completely absent by E9.5

decreased spongiotrophoblast size ( J:144707 )

• a rapid expansion of this layer, found in the wild-type placenta, does not occur at E9.5- E10.5

• as a result, the layer is decreased significantly in volume at E10.5