Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm3.1(CAG-Il17a)Awai}
• Allele Name: targeted mutation 3.1, Ari Waisman
• Allele ID: MGI:3832630
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gt(ROSA)26Sor^tm3.1(CAG-Il17a)Awai/Gt(ROSA)26Sor^+	involves: BALB/c * C57BL/6	MGI:3833580

Genotype
MGI:3833580

ht1

• Allelic Composition: Gt(ROSA)26Sor^{tm3.1(CAG-Il17a)Awai}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Granulocytosis and anemia in Gt(ROSA)26Sor^{tm3.1(CAG-Il17a)Awai}/Gt(ROSA)26Sor⁺ mice

immune system

increased granulocyte number ( J:144710 )

• there is a substantial increase in the number of granulocytes present in the blood, bone marrow and spleen

increased interleukin-17 secretion ( J:144710 )

• an upregulated secretion of IL-17A occurs from cells isolated from bone marrow, spleen, thymus, and mesenteric lymph nodes in unstimulated cultures

skin inflammation ( J:144710 )

• mice show signs of skin inflammation within a few days of birth

growth/size/body

postnatal growth retardation ( J:144710 )

• growth retardation is evident in mice 4-6 days after birth

hematopoietic system

anemia ( J:144710 )

• anemia-like phenotype is noted in these mice

decreased hematocrit ( J:144710 )

• hematocrit is significantly decreased in these mice

decreased hemoglobin content ( J:144710 )

• mice have significantly decreased hemoglobin content

decreased mean corpuscular hemoglobin ( J:144710 )

• is decreased in these mice

decreased mean corpuscular volume ( J:144710 )

• is decreased in these mice

increased granulocyte number ( J:144710 )

• there is a substantial increase in the number of granulocytes present in the blood, bone marrow and spleen

integument

skin inflammation ( J:144710 )

• mice show signs of skin inflammation within a few days of birth