Phenotypes associated with this allele

• Allele Symbol: Tg(Amhr2-Pik3ca*,-GFP)#Lzh
• Allele Name: transgene insertion, Lin Zhang
• Allele ID: MGI:3832594
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Amhr2-Pik3ca*,-GFP)#Lzh/0	involves: C3H * C57BL/6	MGI:3832595

Genotype
MGI:3832595

tg1

• Allelic Composition: Tg(Amhr2-Pik3ca*,-GFP)#Lzh/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Tg(Amhr2-Pik3ca*,-GFP)#Lzh/0 females exhibit ovarian surface epithelium hyperplasia

reproductive system

abnormal ovary morphology ( J:144834 )

♀ • half show hyperplasia in the ovarian surface epithelium by 4 months of age and all show hyperplasia by 10 months of age

abnormal ovarian follicle number ( J:144834 )

♀ • reduced number of follicles

reduced female fertility ( J:144834 )

♀

neoplasm

neoplasm ( J:144834 )

N • despite detection of AMHR2 activation in human ovarian cancer, no epithelial ovarian tumors are detected

endocrine/exocrine glands

abnormal ovary morphology ( J:144834 )

♀ • half show hyperplasia in the ovarian surface epithelium by 4 months of age and all show hyperplasia by 10 months of age

abnormal ovarian follicle number ( J:144834 )

♀ • reduced number of follicles

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	ovarian cancer	DOID:2394	OMIM:167000 OMIM:607893	J:144834