Analysis Tools
immune system
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• there is about a doubling in the number of T cells found in the peritoneum
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• myelopoiesis is enhanced in these mice though not to the degree observed in Lyn null mice
• there is a significant increase in the number of colonies generated by bone marrow cells or splenocytes in response to in vitro culturing with M-CSF
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• there is a slight increase in the number of macrophages in the peripheral lymph tissues
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• there is about a doubling in the number of T cells found in the peritoneum
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• there is a slight increase in the number of macrophages in the peripheral lymph tissues
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• B cells express higher levels of IgM, CD19 and CD23 on the cell surface compared to controls
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• profound reduction in transitional stage 2 B cells
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• about a five-fold reduction in follicular B cells
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• profound reduction in marginal zone B cells
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• spleen cellularity is reduced by more than half due to B cell lymphopenia
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• significant expression of MHCII complexes by circulating B cells suggest these B cells are in an activated state
• B cells have enhanced calcium flux upon activation
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• mice have elevated circulating levels of IgE
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• mice have elevated circulating levels of IgM
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• 10% of mice develop auto-antibodies at 7-9 weeks of age
• incidence of auto-antibodies do not increase with age compared to the 100% incidence of auto-antibodies in homozygote Lyntm1Ard mice over 20 weeks of age
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• all mice have immunoglobulin complex deposition in the kidney by 8 weeks of age
• 86% of mice also have C3 complement deposition in the kidney
• 10% of mice have mild lymphocytic infiltrate in the kidneys by one year of age
• normal note mice fail to develop the severe glomerulonephritic changes that occur to homozygote Lyntm1Ard mice as the age
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renal/urinary system
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• all mice have immunoglobulin complex deposition in the kidney by 8 weeks of age
• 86% of mice also have C3 complement deposition in the kidney
• 10% of mice have mild lymphocytic infiltrate in the kidneys by one year of age
• normal note mice fail to develop the severe glomerulonephritic changes that occur to homozygote Lyntm1Ard mice as the age
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• immunoglobulin complex deposition in the kidney by 8 weeks of age
• 86% of mice also have C3 complement deposition in the kidney
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digestive/alimentary system
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• there is about a doubling in the number of T cells found in the peritoneum
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hematopoietic system
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• myelopoiesis is enhanced in these mice though not to the degree observed in Lyn null mice
• there is a significant increase in the number of colonies generated by bone marrow cells or splenocytes in response to in vitro culturing with M-CSF
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• there is a large increase in the percentage of CD71+ Terr-119+ erthroblasts found in the spleen that is about 6 fold greater than controls
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• there is a slight increase in the number of macrophages in the peripheral lymph tissues
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|
• there is about a doubling in the number of T cells found in the peritoneum
|
|
• there is a slight increase in the number of macrophages in the peripheral lymph tissues
|
|
• B cells express higher levels of IgM, CD19 and CD23 on the cell surface compared to controls
|
|
• profound reduction in transitional stage 2 B cells
|
|
• about a five-fold reduction in follicular B cells
|
|
• profound reduction in marginal zone B cells
|
|
• spleen cellularity is reduced by more than half due to B cell lymphopenia
|
|
• significant expression of MHCII complexes by circulating B cells suggest these B cells are in an activated state
• B cells have enhanced calcium flux upon activation
|
|
• mice have elevated circulating levels of IgE
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• mice have elevated circulating levels of IgM
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