Analysis Tools
mortality/aging
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• mice die within the first day of birth
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hematopoietic system
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• upon activation with PAR4p or convulxin, platelets derived from chimeric mice fail to sustain calcium ion spike observed in wild-type cells, and this effect is more prominent at low doses of the agonists
• following treatment with thapsigargin, platelets derived from chimeric mice fail to exhibit an influx of extracellular calcium ions in the presence of extracellular calcium ions unlike wild-type cells
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• calcium ion-dependent platelet activation, as determined by integrin activation and P-selectin expression, of platelets derived from chimeric mice is impaired at low doses of agonist
• however, platelet aggregation and thrombus formation of platelets derived from chimeric mice are normal
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homeostasis/metabolism
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• upon activation with PAR4p or convulxin, platelets derived from chimeric mice fail to sustain calcium ion spike observed in wild-type cells, and this effect is more prominent at low doses of the agonists
• following treatment with thapsigargin, platelets derived from chimeric mice fail to exhibit an influx of extracellular calcium ions in the presence of extracellular calcium ions unlike wild-type cells
|
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• calcium ion-dependent platelet activation, as determined by integrin activation and P-selectin expression, of platelets derived from chimeric mice is impaired at low doses of agonist
• however, platelet aggregation and thrombus formation of platelets derived from chimeric mice are normal
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