About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Scgb1a1-Il13)2Eli
transgene insertion 2, Jack A Elias
MGI:3832264
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Stat6tm1Gru/Stat6+
Tg(Scgb1a1-Il13)2Eli/? 		involves: 129S2/SvPas * C57BL/6 * CBA MGI:3832413
cx2
 		Stat6tm1Gru/Stat6tm1Gru
Tg(Scgb1a1-Il13)2Eli/? 		involves: 129S2/SvPas * C57BL/6 * CBA MGI:3832414
cx3
 		Stat6tm1Gru/Stat6tm1Gru
Tg(Scgb1a1-Il13)2Eli/?
Tg(Scgb1a1-STAT6)1Erle/? 		involves: 129S2/SvPas * C57BL/6 * CBA * FVB MGI:3832416
cx4
 		Chit1tm1Eli/Chit1tm1Eli
Tg(Scgb1a1-Il13)2Eli/0 		involves: C57BL/6 * CBA MGI:5447953
tg5
 		Tg(Scgb1a1-Il13)2Eli/? involves: C57BL/6 * CBA MGI:3832412


Genotype
MGI:3832413
cx1
Allelic
Composition		 Stat6tm1Gru/Stat6+
Tg(Scgb1a1-Il13)2Eli/?
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat6tm1Gru mutation (4 available); any Stat6 mutation (54 available)
Tg(Scgb1a1-Il13)2Eli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal respiratory system morphology ( J:132385 )
• substantial epithelial fibrosis occurs
abnormal lung morphology ( J:132385 )
• discolored lungs
abnormal lung size ( J:132385 )
• distended lungs
abnormal pulmonary alveolus morphology ( J:132385 )
• alveolar tissue destruction
overexpanded pulmonary alveolus ( J:132385 )
• alveoli are enlarged
abnormal respiratory system physiology ( J:132385 )
• develop airway hyper reactivity
• increased mucus production
respiratory system inflammation ( J:132385 )
• bronchoalveolar lavage contains increased numbers of macrophage, eosinophiles, lymphocytes, and neutrophiles

immune system
respiratory system inflammation ( J:132385 )
• bronchoalveolar lavage contains increased numbers of macrophage, eosinophiles, lymphocytes, and neutrophiles




Genotype
MGI:3832414
cx2
Allelic
Composition		 Stat6tm1Gru/Stat6tm1Gru
Tg(Scgb1a1-Il13)2Eli/?
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat6tm1Gru mutation (4 available); any Stat6 mutation (54 available)
Tg(Scgb1a1-Il13)2Eli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system phenotype ( J:132385 )
N
• do not develop airway hyper reactivity
• normal mucus production
• no proinflamatory effects
• no airway epithelium fibrosis
• lung morphology normal




Genotype
MGI:3832416
cx3
Allelic
Composition		 Stat6tm1Gru/Stat6tm1Gru
Tg(Scgb1a1-Il13)2Eli/?
Tg(Scgb1a1-STAT6)1Erle/?
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat6tm1Gru mutation (4 available); any Stat6 mutation (54 available)
Tg(Scgb1a1-Il13)2Eli mutation (0 available)
Tg(Scgb1a1-STAT6)1Erle mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system phenotype ( J:132385 )
N
• no proinflamatory effects
• no airway epithelium fibrosis
• lung morphology normal
abnormal respiratory system physiology ( J:132385 )
• develop airway hyper reactivity
• increased mucus production




Genotype
MGI:5447953
cx4
Allelic
Composition		 Chit1tm1Eli/Chit1tm1Eli
Tg(Scgb1a1-Il13)2Eli/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chit1tm1Eli mutation (0 available); any Chit1 mutation (32 available)
Tg(Scgb1a1-Il13)2Eli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to bacterial infection ( J:189872 )
• bleomycin-treated mice exhibit reduced pulmonary fibrosis and inflammation compared with control mice




Genotype
MGI:3832412
tg5
Allelic
Composition		 Tg(Scgb1a1-Il13)2Eli/?
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal respiratory system morphology ( J:53612 )
• nuclear enlargement in airway epithelial cells
• airway epithelial cell hypertrophy
• intracellular accumulation of refractile materials in epithelium
• increased collagen deposition in subepithelial regions and in the adventitia of the airways
abnormal pulmonary alveolus morphology ( J:53612 )
• accumulation of needlelike crystals in alveoli and air passages, increasing with age
abnormal pulmonary alveolus wall morphology ( J:53612 )
• alveolar wall rupture observed
abnormal respiratory system physiology ( J:53612 )
• production of neutral and acidic mucus stimulated
respiratory system inflammation ( J:53612 )
• inflammatory response around small and large airways and in neighboring parenchyma
• milder in 1-2 month old mice
• more pronounced in 2-4 month old mice
increased airway resistance ( J:53612 )
• increased baseline airway resistance particularly as mice age
increased airway responsiveness ( J:53612 )
• increased bronchiospastic response to methacholine

immune system
abnormal leukocyte physiology ( J:53612 )
• cells involved in respiratory inflammation predominantly mononuclear
• moderate numbers of enlarged and sometimes multinucleated macrophage
• significant numbers of eosinophiles
• pockets of degenerating inflammatory cells
respiratory system inflammation ( J:53612 )
• inflammatory response around small and large airways and in neighboring parenchyma
• milder in 1-2 month old mice
• more pronounced in 2-4 month old mice

hematopoietic system
abnormal leukocyte physiology ( J:53612 )
• cells involved in respiratory inflammation predominantly mononuclear
• moderate numbers of enlarged and sometimes multinucleated macrophage
• significant numbers of eosinophiles
• pockets of degenerating inflammatory cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory