Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat6tm1Gru mutation
(4 available);
any
Stat6 mutation
(51 available)
Tg(Scgb1a1-Il13)2Eli mutation
(0 available)
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respiratory system
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• substantial epithelial fibrosis occurs
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• alveolar tissue destruction
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• develop airway hyper reactivity
• increased mucus production
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• bronchoalveolar lavage contains increased numbers of macrophage, eosinophiles, lymphocytes, and neutrophiles
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immune system
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• bronchoalveolar lavage contains increased numbers of macrophage, eosinophiles, lymphocytes, and neutrophiles
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat6tm1Gru mutation
(4 available);
any
Stat6 mutation
(51 available)
Tg(Scgb1a1-Il13)2Eli mutation
(0 available)
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respiratory system
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N |
• no proinflamatory effects
• no airway epithelium fibrosis
• do not develop airway hyper reactivity
• normal mucus production
• lung morphology normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat6tm1Gru mutation
(4 available);
any
Stat6 mutation
(51 available)
Tg(Scgb1a1-Il13)2Eli mutation
(0 available)
Tg(Scgb1a1-STAT6)1Erle mutation
(0 available)
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respiratory system
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N |
• no proinflamatory effects
• no airway epithelium fibrosis
• lung morphology normal
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• develop airway hyper reactivity
• increased mucus production
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chit1tm1Eli mutation
(0 available);
any
Chit1 mutation
(32 available)
Tg(Scgb1a1-Il13)2Eli mutation
(0 available)
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immune system
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• bleomycin-treated mice exhibit reduced pulmonary fibrosis and inflammation compared with control mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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respiratory system
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• nuclear enlargement in airway epithelial cells
• airway epithelial cell hypertrophy
• intracellular accumulation of refractile materials in epithelium
• increased collagen deposition in subepithelial regions and in the adventitia of the airways
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• accumulation of needlelike crystals in alveoli and air passages, increasing with age
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• alveolar wall rupture observed
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• production of neutral and acidic mucus stimulated
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• inflammatory response around small and large airways and in neighboring parenchyma
• milder in 1-2 month old mice
• more pronounced in 2-4 month old mice
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• increased baseline airway resistance particularly as mice age
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• increased bronchiospastic response to methacholine
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immune system
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• cells involved in respiratory inflammation predominantly mononuclear
• moderate numbers of enlarged and sometimes multinucleated macrophage
• significant numbers of eosinophiles
• pockets of degenerating inflammatory cells
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• inflammatory response around small and large airways and in neighboring parenchyma
• milder in 1-2 month old mice
• more pronounced in 2-4 month old mice
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hematopoietic system
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• cells involved in respiratory inflammation predominantly mononuclear
• moderate numbers of enlarged and sometimes multinucleated macrophage
• significant numbers of eosinophiles
• pockets of degenerating inflammatory cells
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Analysis Tools