Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga9tm2Des mutation
(0 available);
any
Itga9 mutation
(60 available)
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normal phenotype
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• mice are viable and appear normal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga9tm2Des mutation
(0 available);
any
Itga9 mutation
(60 available)
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respiratory system
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• methacholine-treated mice infected with a cre-expressing adenovirus exhibit increased narrowing in airways compared with control mice
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• lung slices infected with a cre-expressing adenovirus then treated with methacholine exhibit increased in vitro force generation compared with control rings
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga9tm2Des mutation
(0 available);
any
Itga9 mutation
(60 available)
Tg(ACTA2-rtTA)#Des mutation
(0 available)
Tg(tetO-cre)1Jaw mutation
(5 available)
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respiratory system
N |
• mice exhibit normal airway epithelium morphology and no evidence of inflammation
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• methacholine-treated mice exhibit increased narrowing in airways compared with control mice
• lung slices treated with methacholine in vitro exhibit increased narrowing compared with control slices
• spermine has no increase in contraction unlike in control samples
• however, putrescine has no effect on airway contraction
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• excised tracheal rings (with or without epithelium) treated with methacholine exhibit increased in vitro force generation compared with control rings
• lung slices and tracheal rings exhibit increased contractile response to 5-HT compared with control samples
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• in response to acetylcholine
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga9tm2Des mutation
(0 available);
any
Itga9 mutation
(60 available)
Tg(KRT14-cre)1Amc mutation
(2 available)
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vision/eye
N |
• eye size normal
• corneal clarity normal
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• basal cells are shorter than in controls and are wider
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• thinner than controls but with a similar number of layers
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• cornea is thinner, 50um as compared to 62um
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homeostasis/metabolism