About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Ntrk3-EGFP)BM45Gsat
transgene insertion BM45, GENSAT Project at Rockefeller University
MGI:3831877
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Etv1tm2Tmj/Etv1tm2Tmj
Tg(Ntrk3-EGFP)BM45Gsat/0 		involves: 129S1/Sv * FVB/N MGI:5506522
cx2
 		Plxna1tm1Tmj/Plxna1tm1Tmj
Tg(Ntrk3-EGFP)BM45Gsat/0 		involves: 129S/SvEv * C57BL/6J * FVB/N MGI:3831890


Genotype
MGI:5506522
cx1
Allelic
Composition		 Etv1tm2Tmj/Etv1tm2Tmj
Tg(Ntrk3-EGFP)BM45Gsat/0
Genetic
Background		 involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv1tm2Tmj mutation (0 available); any Etv1 mutation (44 available)
Tg(Ntrk3-EGFP)BM45Gsat mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal axon guidance ( J:197913 )
• in P5-6 mutants, almost complete depletion in the laterally-targeted pSN axon fascicle at T9, L2 and L5 spinal cord levels; medially-oriented pSN axons are greatly reduced in number at all segmental levels compared to controls

nervous system
abnormal axon guidance ( J:197913 )
• in P5-6 mutants, almost complete depletion in the laterally-targeted pSN axon fascicle at T9, L2 and L5 spinal cord levels; medially-oriented pSN axons are greatly reduced in number at all segmental levels compared to controls
decreased sensory neuron number ( J:197913 )
• number of proprioceptive sensory neurons (pSNs) detected in DRGs at level of L2 are decreased by 30% at P0 and by P10, there is 80% loss; at L5 levels, pSN number is decreased by 40% at P0 and P10




Genotype
MGI:3831890
cx2
Allelic
Composition		 Plxna1tm1Tmj/Plxna1tm1Tmj
Tg(Ntrk3-EGFP)BM45Gsat/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna1tm1Tmj mutation (0 available); any Plxna1 mutation (75 available)
Tg(Ntrk3-EGFP)BM45Gsat mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal proprioceptive neuron morphology ( J:144660 )
• from E12.5 to E16.5, the proprioceptive axons are displaced into the neuropil of the dorsal spinal cord unlike in wild-type mice
• from P0 to P8, over 95% of displaced proprioceptive axons shaft located in the medial half of the superficial dorsal horn unlike in wild-type mice, and the incidence of proprioceptive axon shafts within the medial half of the dorsal funiculus is decreased 95% compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory