Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna1tm1Tmj mutation
(0 available);
any
Plxna1 mutation
(75 available)
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immune system
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• increased lymphatic branching complexity similar to Sema3gtm1(KOMP)Vlcg/Sema3ftm1.2Ddg heterozygotes
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vision/eye
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N |
• mice exhibit normal retinal stratification
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna1tm1Tmj mutation
(0 available);
any
Plxna1 mutation
(75 available)
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nervous system
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• at P8, the number of MAG+ and MBP+ oligodendrocytes is increased greater than 10-fold compared to in wild-type mice, and over 95% of ectopic MAG+ and MBP+ oligodendrocytes are found in the medial half of the superficial dorsal horn unlike in wild-type mice
• MAG+ and MBP+ oligodendrocytes are associated with Pvalb+ proprioceptive axonal shafts in the medial half of the superficial dorsal horn
• MAG+ oligodendrocytes displace vGlut1+ (Slc17a7+) axons
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna1tm1Tmj mutation
(0 available);
any
Plxna1 mutation
(75 available)
Plxna3tm1Matl mutation
(1 available);
any
Plxna3 mutation
(13 available)
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vision/eye
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• multiple amacrine cell subtypes exhibit aberrant neurite extension into the inner nuclear layer and outer plexiform layer
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• multiple retinal bipolar cell subtypes exhibit aberrant neurite extension into the inner nuclear layer and outer plexiform layer
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• multiple retinal ganglion subtypes exhibit aberrant neurite extension into the inner nuclear layer and outer plexiform layer
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• multiple retinal ganglion, amacrine and bipolar cell subtypes exhibit aberrant neurite extension into the inner nuclear layer and outer plexiform layer
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• exhibit severe, fully penetrant and expressive, defects in inner plexiform layer neurite targeting
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• multiple retinal ganglion, amacrine and bipolar cell subtypes exhibit aberrant neurite extension into the inner nuclear layer and outer plexiform layer
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nervous system
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• exhibit severe, fully penetrant and expressive, defects in inner plexiform layer neurite targeting
• multiple retinal ganglion, amacrine and bipolar cell subtypes exhibit aberrant neurite extension into the inner nuclear layer and outer plexiform layer
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• multiple amacrine cell subtypes exhibit aberrant neurite extension into the inner nuclear layer and outer plexiform layer
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• multiple retinal bipolar cell subtypes exhibit aberrant neurite extension into the inner nuclear layer and outer plexiform layer
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• multiple retinal ganglion subtypes exhibit aberrant neurite extension into the inner nuclear layer and outer plexiform layer
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna1tm1Tmj mutation
(0 available);
any
Plxna1 mutation
(75 available)
Tg(Pvalb-EGFP)B13Zjh mutation
(0 available)
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nervous system
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N |
• early differentiation and peripheral projections of proprioceptive sensory neurons is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna1tm1Tmj mutation
(0 available);
any
Plxna1 mutation
(75 available)
Tg(Ntrk3-EGFP)BM45Gsat mutation
(1 available)
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nervous system
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• from E12.5 to E16.5, the proprioceptive axons are displaced into the neuropil of the dorsal spinal cord unlike in wild-type mice
• from P0 to P8, over 95% of displaced proprioceptive axons shaft located in the medial half of the superficial dorsal horn unlike in wild-type mice, and the incidence of proprioceptive axon shafts within the medial half of the dorsal funiculus is decreased 95% compared to in wild-type mice
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Analysis Tools