Phenotypes associated with this allele

• Allele Symbol: Dock3^tm1Dasc
• Allele Name: targeted mutation 1, David Schubert
• Allele ID: MGI:3831156
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dock3^tm1Dasc/Dock3^tm1Dasc	B6.Cg-Dock3^tm1Dasc	MGI:3831158

Genotype
MGI:3831158

hm1

• Allelic Composition: Dock3^tm1Dasc/Dock3^tm1Dasc
• Genetic Background: B6.Cg-Dock3^tm1Dasc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:144341 )

N • despite reduction in the size of the cortex and cerebrum, the overall brain and spinal cord structure are normally organized

abnormal microglial cell physiology ( J:144341 )

• at 2 and 20 months, mice exhibit microglial activation in the spinal cord

abnormal cerebral cortex morphology ( J:144341 )

• the cortex is slightly smaller than in wild-type mice

small cerebellum ( J:144341 )

• slightly

L5 dorsal root ganglion hypertrophy ( J:144341 )

• mice exhibit an increase in fiber diameter size

abnormal ventral spinal root morphology ( J:144341 )

• mice exhibit an increase in fiber diameter size

abnormal spinal cord morphology ( J:144341 )

• the spinal cord accumulates autophagic vacuoles

axonal dystrophy ( J:144341 )

• neurofilaments accumulate in the cerebellum, brainstem, habenula, and spinal cord unlike in wild-type mice suggesting axonal dystrophy

• degenerating axons with swelling and many vacuoles are observed in the spinal cord

• however, myelination of axons is normal

axonal spheroids ( J:144341 )

• detected by neurofilament antibodies

abnormal axonal transport ( J:144341 )

• anterograde and retrograde transport are impaired

behavior/neurological

abnormal motor learning ( J:144341 )

• motor learning in a rotarod assay is partially impaired compared to in wild-type mice

limb grasping ( J:144341 )

• when suspended by the tail, mice exhibit spinning and clasping

ataxia ( J:144341 )

impaired coordination ( J:144341 )

• latency to fall on a rotarod assay is decreased

impaired swimming ( J:144341 )

weakness ( J:144341 )

• mice exhibit limb weakness

abnormal gait ( J:144341 )

decreased locomotor activity ( J:144341 )

• in an open field test

muscle

muscular atrophy ( J:144341 )

• some mice exhibit atrophic fibers in both slow- and fast-twitch muscles

immune system

abnormal microglial cell physiology ( J:144341 )

• at 2 and 20 months, mice exhibit microglial activation in the spinal cord

hematopoietic system

abnormal microglial cell physiology ( J:144341 )

• at 2 and 20 months, mice exhibit microglial activation in the spinal cord