Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Siaetm1.2Avrk mutation
(0 available);
any
Siae mutation
(33 available)
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immune system
N |
• unlike mice on a C57BL/6NHsd background for 10 generations, mice subsequently bred to a C57BL/6J background for an additional 13 generation exhibit normal MZ B cells development and CD8+ memory T cells
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock2m1Hsd mutation
(0 available);
any
Dock2 mutation
(142 available)
Siaetm1.2Avrk mutation
(0 available);
any
Siae mutation
(33 available)
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Glomerulonephritis in Siaetm1.2Avrk/Siaetm1.2Avrk mice
immune system
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• the percentage of B1a B cells in the peritoneum is reduced by about half
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• there is a selective loss of recirculating follicular phenotype B cells from the perisinusoidal niche of bone marrow
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• numbers of IgMhiIgDhiCD21hiMZ B cell
precursors (MZP), as well as IgMhiIgDlowCD21hiMZ B cells, are severely reduced in the spleen compared to controls
(J:144035)
• MZP B cells are reduced 10.5 fold and MZ B cells are reduced 23 fold compared to controls
(J:144035)
• Background Sensitivity: unlike mice bred to a C57BL/6J background for an additional 13 generation, mice bred to a C57BL/6NHsd background for only 10 generations exhibit loss of marginal zone B cells compared with wild-type mice
(J:231437)
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• the percentage of B1b B cells in the peritoneum is increased by over half
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• Background Sensitivity: unlike mice bred to a C57BL/6J background for an additional 13 generation, mice bred to a C57BL/6NHsd background for only 10 generations exhibit an increase in memory T cells in blood and spleen compared with wild-type mice
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• T cell numbers are slightly reduced in the thymus and almost 2-fold reduced in the spleen
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• there is a 2.4 fold decrease in the number of cells in the spleen compared to controls
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• splenic B cells stimulated with anti-IgM have enhanced calcium influx
• enhanced calcium influx was observed for newly formed B cells, follicular B cells, and marginal zone B cells
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• B cells proliferate faster than controls with sub-optimal doses of anti-IgM
• the proliferation advantage is diminished with higher doses and/or longer stimulation times possibly from increased rates of apoptosis
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• IgE levels are significantly higher than in controls
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• IgG1 levels are significantly higher than in controls
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• lower levels of antigen-specific IgG2a are present after immunization
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• IgG2b levels are significantly higher than in controls
• however, lower levels of antigen-specific IgG2b are present after immunization
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• lower levels of antigen-specific IgG3 are present after immunization
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• IgM levels are significantly higher than in controls
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• higher levels of anti-DS DNA antibodies than in controls are found in the sera of mice 20-60 weeks of age
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• higher levels of anti-histone antibodies than in controls are found in the sera of mice 20-60 weeks of age
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• higher levels of anti-SS DNA antibodies than in controls are found in the sera of mice 20-60 weeks of age
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• mutants develop an immune complex-glomerulonephritis
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hematopoietic system
|
• the percentage of B1a B cells in the peritoneum is reduced by about half
|
|
• there is a selective loss of recirculating follicular phenotype B cells from the perisinusoidal niche of bone marrow
|
|
• numbers of IgMhiIgDhiCD21hiMZ B cell
precursors (MZP), as well as IgMhiIgDlowCD21hiMZ B cells, are severely reduced in the spleen compared to controls
(J:144035)
• MZP B cells are reduced 10.5 fold and MZ B cells are reduced 23 fold compared to controls
(J:144035)
• Background Sensitivity: unlike mice bred to a C57BL/6J background for an additional 13 generation, mice bred to a C57BL/6NHsd background for only 10 generations exhibit loss of marginal zone B cells compared with wild-type mice
(J:231437)
|
|
• the percentage of B1b B cells in the peritoneum is increased by over half
|
|
• Background Sensitivity: unlike mice bred to a C57BL/6J background for an additional 13 generation, mice bred to a C57BL/6NHsd background for only 10 generations exhibit an increase in memory T cells in blood and spleen compared with wild-type mice
|
|
• T cell numbers are slightly reduced in the thymus and almost 2-fold reduced in the spleen
|
|
• there is a 2.4 fold decrease in the number of cells in the spleen compared to controls
|
|
• splenic B cells stimulated with anti-IgM have enhanced calcium influx
• enhanced calcium influx was observed for newly formed B cells, follicular B cells, and marginal zone B cells
|
|
• B cells proliferate faster than controls with sub-optimal doses of anti-IgM
• the proliferation advantage is diminished with higher doses and/or longer stimulation times possibly from increased rates of apoptosis
|
|
• IgE levels are significantly higher than in controls
|
|
• IgG1 levels are significantly higher than in controls
|
|
• lower levels of antigen-specific IgG2a are present after immunization
|
|
• IgG2b levels are significantly higher than in controls
• however, lower levels of antigen-specific IgG2b are present after immunization
|
|
• lower levels of antigen-specific IgG3 are present after immunization
|
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• IgM levels are significantly higher than in controls
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renal/urinary system
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• mutants develop an immune complex-glomerulonephritis
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cellular
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• B cells proliferate faster than controls with sub-optimal doses of anti-IgM
• the proliferation advantage is diminished with higher doses and/or longer stimulation times possibly from increased rates of apoptosis
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cmahtm1Avrk mutation
(5 available);
any
Cmah mutation
(37 available)
Dock2m1Hsd mutation
(0 available);
any
Dock2 mutation
(142 available)
Siaetm1.2Avrk mutation
(0 available);
any
Siae mutation
(33 available)
|
|
|
immune system
|
• there is a selective loss of recirculating follicular phenotype B cells from the perisinusoidal niche of bone marrow
|
|
• numbers of IgMhiIgDhiCD21hiMZ B cell
precursors (MZP), as well as IgMhiIgDlowCD21hiMZ B cells, are severely reduced in the spleen compared to controls
|
|
• splenic B cells stimulated with anti-IgM have enhanced calcium influx
• enhanced calcium influx was observed for newly formed B cells, follicular B cells, and marginal zone B cells
|
hematopoietic system
|
• there is a selective loss of recirculating follicular phenotype B cells from the perisinusoidal niche of bone marrow
|
|
• numbers of IgMhiIgDhiCD21hiMZ B cell
precursors (MZP), as well as IgMhiIgDlowCD21hiMZ B cells, are severely reduced in the spleen compared to controls
|
|
• splenic B cells stimulated with anti-IgM have enhanced calcium influx
• enhanced calcium influx was observed for newly formed B cells, follicular B cells, and marginal zone B cells
|