Phenotypes associated with this allele

• Allele Symbol: Rims1^tm3.1Sud
• Allele Name: targeted mutation 3.1, Thomas C Sudhof
• Allele ID: MGI:3830681
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rims1^tm3.1Sud/Rims1^tm3.1Sud	involves: 129P2/OlaHsd * 129S/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3830689
hm2	Rims1^tm3.1Sud/Rims1^tm3.1Sud	involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3830688

Genotype
MGI:3830689

hm1

• Allelic Composition: Rims1^tm3.1Sud/Rims1^tm3.1Sud
• Genetic Background: involves: 129P2/OlaHsd * 129S/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:143053 )

• 75% of mice die before P7

Genotype
MGI:3830688

hm2

• Allelic Composition: Rims1^tm3.1Sud/Rims1^tm3.1Sud
• Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL

mortality/aging

postnatal lethality ( J:143053 )

• 75% of mice die before P7

nervous system

impaired synaptic plasticity ( J:143053 )

• presynaptic long-term plasticity is abolished unlike in wild-type mice

abnormal inhibitory postsynaptic currents ( J:143053 )

• miniature inhibitory postsynaptic current (mIPSC) frequency is decreased compared to in wild-type mice

• reduction in mIPSC is more severe than in Rims1^tm1Sud homozygotes

• evoked inhibitory postsynaptic current (eIPSC) amplitude is reduced compared to in wild-type mice

• reduction in eIPSC is more severe than in Rims1^tm1Sud homozygotes

enhanced paired-pulse facilitation ( J:143053 )

abnormal paired-pulse inhibition ( J:143053 )

• paired pulse depression is decreased compared to in wild-type mice that is more pronounced than in Rims1^tm1Sud homozygotes