Phenotypes associated with this allele

• Allele Symbol: Birc3^tm1Rgk
• Allele Name: targeted mutation 1, Robert G Korneluk
• Allele ID: MGI:3830313
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Birc3^tm1Rgk/Birc3^tm1Rgk	B6.129X1-Birc3^tm1Rgk	MGI:3830359

Genotype
MGI:3830359

hm1

• Allelic Composition: Birc3^tm1Rgk/Birc3^tm1Rgk
• Genetic Background: B6.129X1-Birc3^tm1Rgk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte cell number ( J:144012 )

• cell counts are normal

• total lymphocyte numbers are unaffected by LPS injection

decreased macrophage cell number ( J:144012 )

• peritoneum derived macrophage numbers are significantly reduced 5 hours after LPS injection

• precipitous drop in liver macrophage numbers 6 hours after LPS injection

abnormal immune cell physiology ( J:144012 )

abnormal T cell physiology ( J:144012 )

• resistance to apoptosis is not enhanced by LPS pretreatment

abnormal macrophage physiology ( J:144012 )

• cytokine production is normal and responds normally in culture

• resistance to apoptosis is not enhanced by LPS pretreatment

• both peritoneal and splenic macrophage are sensitive to apoptotic stimuli 5 hours after LPS injection

abnormal cytokine secretion ( J:144012 )

abnormal interleukin-1 beta secretion ( J:144012 )

• response to LPS peaks at about 4 hours but much later for controls

abnormal interleukin-12 secretion ( J:144012 )

• response to LPS becomes attenuated by 6 hours after injection

abnormal tumor necrosis factor secretion ( J:144012 )

• response to LPS drops off by 10 hours after injection while remaining high in controls until death

decreased susceptibility to endotoxin shock ( J:144012 )

• early signs of sepsis after LPS injection include eye exudate and ruffled fur but signs do not persist

• resistant to fatality due to injections of up to 40mg/kg of lipopolysaccharide

• LD50 dose of LPS is about 100mg/kg

• survive up to 7 days after injections of 200mg/kg of LPS whereas controls die within 24 hours when given 40mg/kg

• normal sensitivity to alpha FAS protein, platelet activating factor, and D-galactosamine

hematopoietic system

abnormal leukocyte cell number ( J:144012 )

• cell counts are normal

• total lymphocyte numbers are unaffected by LPS injection

decreased macrophage cell number ( J:144012 )

• peritoneum derived macrophage numbers are significantly reduced 5 hours after LPS injection

• precipitous drop in liver macrophage numbers 6 hours after LPS injection

abnormal T cell physiology ( J:144012 )

• resistance to apoptosis is not enhanced by LPS pretreatment

abnormal macrophage physiology ( J:144012 )

• cytokine production is normal and responds normally in culture

• resistance to apoptosis is not enhanced by LPS pretreatment

• both peritoneal and splenic macrophage are sensitive to apoptotic stimuli 5 hours after LPS injection