Phenotypes associated with this allele

• Allele Symbol: Rptor⁺
• Allele Name: wild type
• Allele ID: MGI:3829754
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Rptor^tm2b(EUCOMM)Wtsi/Rptor^+	C57BL/6N-Rptor^tm2b(EUCOMM)Wtsi/H	MGI:5887506
ht2	Rptor^tm1.1Rueg/Rptor^+	involves: 129S1/SvImJ * BALB/cJ * C57BL/6J	MGI:3829755
cn3	Gt(ROSA)26Sor^tm4(Wnt7b)Flng/Gt(ROSA)26Sor^+ Rptor^tm1Rueg/Rptor^+ Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:5613583
cn4	Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Rptor^tm1.1Dmsa/Rptor^+ Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129S/SvEv * C57BL/10 * CBA/Ca	MGI:6513971
cx5	Pten^tm1Rps/Pten^+ Rptor^tm1Lex/Rptor^+	involves: 129S/SvEvBrd * 129S1/Sv * C57BL/6	MGI:4848144

Genotype
MGI:5887506

ht1

• Allelic Composition: Rptor^{tm2b(EUCOMM)Wtsi}/Rptor⁺
• Genetic Background: C57BL/6N-Rptor^{tm2b(EUCOMM)Wtsi}/H
• Cell Lines: EPD0489_3_H12

Data Sources

IMPC Data for Rptor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal sinus arrhythmia ( J:211773 )

♀

IMPC - HAR

Genotype
MGI:3829755

ht2

• Allelic Composition: Rptor^tm1.1Rueg/Rptor⁺
• Genetic Background: involves: 129S1/SvImJ * BALB/cJ * C57BL/6J

cellular

abnormal cell differentiation ( J:143749 )

• mouse embryonic fibroblasts (MEFs) exhibit reduced differentiation into adipocyte-like cells compared to wild-type MEFs

Genotype
MGI:5613583

cn3

• Allelic Composition: Gt(ROSA)26Sor^{tm4(Wnt7b)Flng}/Gt(ROSA)26Sor⁺; Rptor^tm1Rueg/Rptor⁺; Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

skeleton

abnormal bone marrow cavity morphology ( J:208766 )

• when cre expression is suppressed by doxycycline treatment until 1 month of age the marrow cavity is decreased

increased bone mass ( J:208766 )

• when cre expression is suppressed by doxycycline treatment until 1 month of age mice show very high bone mass 3 weeks after stopping doxycycline treatment

Genotype
MGI:6513971

cn4

• Allelic Composition: Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur; Rptor^tm1.1Dmsa/Rptor⁺; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129S/SvEv * C57BL/10 * CBA/Ca

immune system

abnormal NK cell morphology ( J:282535 )

• reduced cell size and granularity but not as much as in Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ mice

decreased NK cell number ( J:282535 )

• although not as decreased in Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ mice

small spleen ( J:282535 )

hematopoietic system

abnormal NK cell morphology ( J:282535 )

• reduced cell size and granularity but not as much as in Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ mice

decreased NK cell number ( J:282535 )

• although not as decreased in Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ mice

small spleen ( J:282535 )

Genotype
MGI:4848144

cx5

• Allelic Composition: Pten^tm1Rps/Pten⁺; Rptor^tm1Lex/Rptor⁺
• Genetic Background: involves: 129S/SvEvBrd * 129S1/Sv * C57BL/6

mortality/aging

mortality/aging ( J:144810 )

N • mutants exhibit a similar lifespan as single heterozygous Pten mice