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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rptortm1.1Rueg
targeted mutation 1.1 Markus A Reugg
MGI:3829706
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rptortm1.1Rueg/Rptortm1.1Rueg involves: 129S1/SvImJ * BALB/cJ * C57BL/6J MGI:3829753
ht2
 		Rptortm1.1Rueg/Rptor+ involves: 129S1/SvImJ * BALB/cJ * C57BL/6J MGI:3829755


Genotype
MGI:3829753
hm1
Allelic
Composition		 Rptortm1.1Rueg/Rptortm1.1Rueg
Genetic
Background		 involves: 129S1/SvImJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rptortm1.1Rueg mutation (0 available); any Rptor mutation (114 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:143749 )
• similar to in Rptortm1Lex homozygotes, mice exhibit early embryonic lethality




Genotype
MGI:3829755
ht2
Allelic
Composition		 Rptortm1.1Rueg/Rptor+
Genetic
Background		 involves: 129S1/SvImJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rptortm1.1Rueg mutation (0 available); any Rptor mutation (114 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell differentiation ( J:143749 )
• mouse embryonic fibroblasts (MEFs) exhibit reduced differentiation into adipocyte-like cells compared to wild-type MEFs




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory