All Phenotypes Igk-J<tm1(CD4*)Mss> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igk-J^tm1(CD4*)Mss
targeted mutation 1, Mark S Schlissel
MGI:3829660

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Igkc^tm1(IGKC)Mnz/Igkc⁺ Igk-J^tm1(CD4*)Mss/Igk-J⁺	involves: 129S4/SvJae	MGI:3829707

Allelic Composition	Igkc^tm1(IGKC)Mnz/Igkc⁺ Igk-J^tm1(CD4*)Mss/Igk-J⁺
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkc^tm1(IGKC)Mnz mutation (2 available); any Igkc mutation (9 available)
Igk-J^tm1(CD4*)Mss mutation (0 available); any Igk-J mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal immunoglobulin light chain V-J recombination ( J:143876 )

• mice were bred to carry the two mutant alleles in trans

• a 2:1 skew in favor of expression of the Igk-C^tm1(IGKC)Mnz allele among immature and mature B cells suggests the CD4 knock-in allele causes a recombination defect

hematopoietic system

abnormal immunoglobulin light chain V-J recombination ( J:143876 )

• mice were bred to carry the two mutant alleles in trans

• a 2:1 skew in favor of expression of the Igk-C^tm1(IGKC)Mnz allele among immature and mature B cells suggests the CD4 knock-in allele causes a recombination defect

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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