All Phenotypes Tg(Ttr-cre)1Hadj MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Ttr-cre)1Hadj
transgene insertion 1, Anna-Katerina Hadjantonakis
MGI:3829595

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rac1^tm1Tyb/Rac1^tm2Tyb Tg(Ttr-cre)1Hadj/0	involves: 129S4/SvJae * C3H * C57BL/6 * CBA/J	MGI:5050120
cn2	Porcn^tm1.1Jrt/Porcn⁺ Tg(Ttr-cre)1Hadj/0	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * CBA/J	MGI:5523430
cn3	Arl8b^tm1Kkon/Arl8b^tm1Kkon Tg(Ttr-cre)1Hadj/0	involves: C57BL/6J * C57BL/6N * CBA/J	MGI:6107945
cn4	Arhgef7^{tm1c(EUCOMM)Wtsi}/Arhgef7^{tm1c(EUCOMM)Wtsi} Tg(Ttr-cre)1Hadj/0	involves: C57BL/6J * C57BL/6N * CBA/J	MGI:6841002

Allelic Composition	Rac1^tm1Tyb/Rac1^tm2Tyb Tg(Ttr-cre)1Hadj/0
Genetic Background	involves: 129S4/SvJae * C3H * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rac1^tm1Tyb mutation (0 available); any Rac1 mutation (21 available)
Rac1^tm2Tyb mutation (0 available); any Rac1 mutation (21 available)
Tg(Ttr-cre)1Hadj mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:166095 )

• survive longer than germ line null mice, up to E8.25

embryo

abnormal anterior visceral endoderm cell migration ( J:166095 )

• migration of anterior visceral endoderm cells is disrupted

• defect in migration is not as severe as in germ line null mice probably due to the timing of cre expression

abnormal rostral-caudal axis patterning ( J:166095 )

• expression analysis indicates a defect in the initial specification of the AP axis in most embryos

embryonic-extraembryonic boundary constriction ( J:166095 )

• constriction at the boundary between embryonic and extraembryonic regions

abnormal extraembryonic endoderm formation ( J:173526 )

• visceral endoderm cells fail to form a border around the midline structures

craniofacial

abnormal craniofacial development ( J:166095 )

• abnormal headfolds at E7.5

cellular

abnormal anterior visceral endoderm cell migration ( J:166095 )

• migration of anterior visceral endoderm cells is disrupted

• defect in migration is not as severe as in germ line null mice probably due to the timing of cre expression

Allelic Composition	Porcn^tm1.1Jrt/Porcn⁺ Tg(Ttr-cre)1Hadj/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcn^tm1.1Jrt mutation (1 available); any Porcn mutation (18 available)
Tg(Ttr-cre)1Hadj mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:198636 )

N	• heterozygous females present at the expected ratio at weaning

Allelic Composition	Arl8b^tm1Kkon/Arl8b^tm1Kkon Tg(Ttr-cre)1Hadj/0
Genetic Background	involves: C57BL/6J * C57BL/6N * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arl8b^tm1Kkon mutation (0 available); any Arl8b mutation (24 available)
Tg(Ttr-cre)1Hadj mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

decreased embryo size ( J:245627 )

• at E8.5

abnormal embryonic tissue physiology ( J:245627 )

• decreased amino acid levels in the embryo

abnormal visceral yolk sac morphology ( J:245627 )

• the visceral yolk sac is relatively opaque at E8.5

abnormal visceral yolk sac endoderm morphology ( J:245627 )

• hypertrophic visceral yolk sac endoderm with accumulation of vesicles at E8.5

abnormal extraembryonic tissue physiology ( J:245627 )

• accumulation of maternal albumin and IgG and impaired maturation of cathepsin L in the visceral yolk sac

• reduced levels of almost all amino acids and metabolites produced by the central metabolic pathways in the visceral yolk sac

homeostasis/metabolism

abnormal amino acid level ( J:245627 )

• decreased amino acid levels in the embryo

growth/size/body

decreased embryo size ( J:245627 )

• at E8.5

Allelic Composition	Arhgef7^{tm1c(EUCOMM)Wtsi}/Arhgef7^{tm1c(EUCOMM)Wtsi} Tg(Ttr-cre)1Hadj/0
Genetic Background	involves: C57BL/6J * C57BL/6N * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef7^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Arhgef7 mutation (53 available)
Tg(Ttr-cre)1Hadj mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal anterior visceral endoderm cell migration ( J:217373 )

• with reduced directional persistence of migration, small reduction of individual cell migration speed, loss of collectivity, and impaired directing of protrusive activity

abnormal primitive streak morphology ( J:217373 )

• double axis at E7.5

cellular

abnormal anterior visceral endoderm cell migration ( J:217373 )

• with reduced directional persistence of migration, small reduction of individual cell migration speed, loss of collectivity, and impaired directing of protrusive activity

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23