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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Ttr-cre)1Hadj
transgene insertion 1, Anna-Katerina Hadjantonakis
MGI:3829595
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rac1tm1Tyb/Rac1tm2Tyb
Tg(Ttr-cre)1Hadj/0 		involves: 129S4/SvJae * C3H * C57BL/6 * CBA/J MGI:5050120
cn2
 		Porcntm1.1Jrt/Porcn+
Tg(Ttr-cre)1Hadj/0 		involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * CBA/J MGI:5523430
cn3
 		Arl8btm1Kkon/Arl8btm1Kkon
Tg(Ttr-cre)1Hadj/0 		involves: C57BL/6J * C57BL/6N * CBA/J MGI:6107945
cn4
 		Arhgef7tm1c(EUCOMM)Wtsi/Arhgef7tm1c(EUCOMM)Wtsi
Tg(Ttr-cre)1Hadj/0 		involves: C57BL/6J * C57BL/6N * CBA/J MGI:6841002


Genotype
MGI:5050120
cn1
Allelic
Composition		 Rac1tm1Tyb/Rac1tm2Tyb
Tg(Ttr-cre)1Hadj/0
Genetic
Background		 involves: 129S4/SvJae * C3H * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rac1tm1Tyb mutation (0 available); any Rac1 mutation (26 available)
Rac1tm2Tyb mutation (0 available); any Rac1 mutation (26 available)
Tg(Ttr-cre)1Hadj mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:166095 )
• survive longer than germ line null mice, up to E8.25

embryo
abnormal anterior visceral endoderm cell migration ( J:166095 )
• migration of anterior visceral endoderm cells is disrupted
• defect in migration is not as severe as in germ line null mice probably due to the timing of cre expression
abnormal rostral-caudal axis patterning ( J:166095 )
• expression analysis indicates a defect in the initial specification of the AP axis in most embryos
embryonic-extraembryonic boundary constriction ( J:166095 )
• constriction at the boundary between embryonic and extraembryonic regions
abnormal extraembryonic endoderm formation ( J:173526 )
• visceral endoderm cells fail to form a border around the midline structures

craniofacial
abnormal craniofacial development ( J:166095 )
• abnormal headfolds at E7.5

cellular
abnormal anterior visceral endoderm cell migration ( J:166095 )
• migration of anterior visceral endoderm cells is disrupted
• defect in migration is not as severe as in germ line null mice probably due to the timing of cre expression




Genotype
MGI:5523430
cn2
Allelic
Composition		 Porcntm1.1Jrt/Porcn+
Tg(Ttr-cre)1Hadj/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcntm1.1Jrt mutation (2 available); any Porcn mutation (19 available)
Tg(Ttr-cre)1Hadj mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:198636 )
N
• heterozygous females present at the expected ratio at weaning




Genotype
MGI:6107945
cn3
Allelic
Composition		 Arl8btm1Kkon/Arl8btm1Kkon
Tg(Ttr-cre)1Hadj/0
Genetic
Background		 involves: C57BL/6J * C57BL/6N * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arl8btm1Kkon mutation (0 available); any Arl8b mutation (23 available)
Tg(Ttr-cre)1Hadj mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryonic tissue physiology ( J:245627 )
• decreased amino acid levels in the embryo
abnormal visceral yolk sac morphology ( J:245627 )
• the visceral yolk sac is relatively opaque at E8.5
abnormal visceral yolk sac endoderm morphology ( J:245627 )
• hypertrophic visceral yolk sac endoderm with accumulation of vesicles at E8.5
abnormal extraembryonic tissue physiology ( J:245627 )
• accumulation of maternal albumin and IgG and impaired maturation of cathepsin L in the visceral yolk sac
• reduced levels of almost all amino acids and metabolites produced by the central metabolic pathways in the visceral yolk sac

homeostasis/metabolism
abnormal amino acid level ( J:245627 )
• decreased amino acid levels in the embryo

growth/size/body
decreased embryo size ( J:245627 )
• at E8.5




Genotype
MGI:6841002
cn4
Allelic
Composition		 Arhgef7tm1c(EUCOMM)Wtsi/Arhgef7tm1c(EUCOMM)Wtsi
Tg(Ttr-cre)1Hadj/0
Genetic
Background		 involves: C57BL/6J * C57BL/6N * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef7tm1c(EUCOMM)Wtsi mutation (0 available); any Arhgef7 mutation (53 available)
Tg(Ttr-cre)1Hadj mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal anterior visceral endoderm cell migration ( J:217373 )
• with reduced directional persistence of migration, small reduction of individual cell migration speed, loss of collectivity, and impaired directing of protrusive activity
abnormal primitive streak morphology ( J:217373 )
• double axis at E7.5

cellular
abnormal anterior visceral endoderm cell migration ( J:217373 )
• with reduced directional persistence of migration, small reduction of individual cell migration speed, loss of collectivity, and impaired directing of protrusive activity




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory