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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Glrx3Gt(RRF094)Byg
gene trap RRF094, BayGenomics
MGI:3829374
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Glrx3Gt(RRF094)Byg/Glrx3Gt(RRF094)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:3829375
ht2
 		Glrx3Gt(RRF094)Byg/Glrx3+ involves: 129P2/OlaHsd * C57BL/6 MGI:3829376


Genotype
MGI:3829375
hm1
Allelic
Composition		 Glrx3Gt(RRF094)Byg/Glrx3Gt(RRF094)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glrx3Gt(RRF094)Byg mutation (0 available); any Glrx3 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:143577 )
• mice die between E12.5 and E14.5; none are recovered past E14.5

cardiovascular system
pericardial effusion ( J:190794 )
• in some mice at E12.5
intracranial hemorrhage ( J:143577 )
• at E12.5, mice exhibit hemorrhages in the head

growth/size/body
decreased embryo size ( J:143577 , J:190794 )
• at E12.5 (J:143577)
• at E12.5 (J:190794)

embryo
decreased embryo size ( J:143577 , J:190794 )
• at E12.5 (J:143577)
• at E12.5 (J:190794)
open neural tube ( J:190794 )
• open anterior neural tube in some mice at E12.5

cellular
binucleate ( J:190794 )
• more binucleated cells are seen in cultured MEFs
abnormal cell cycle ( J:190794 )
• in culture MEFs show an increase in the proportion of cells in the G2/M phase and more binucleated cells are seen
abnormal cell death ( J:190794 )
• MEFs do not survive beyond passage 4

nervous system
intracranial hemorrhage ( J:143577 )
• at E12.5, mice exhibit hemorrhages in the head
open neural tube ( J:190794 )
• open anterior neural tube in some mice at E12.5

homeostasis/metabolism
pericardial effusion ( J:190794 )
• in some mice at E12.5




Genotype
MGI:3829376
ht2
Allelic
Composition		 Glrx3Gt(RRF094)Byg/Glrx3+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glrx3Gt(RRF094)Byg mutation (0 available); any Glrx3 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased cardiac muscle contractility ( J:143577 )
• cardiomyocytes exhibit a 23% decrease in cell shortening, a 29% decrease in maximal rate of contraction, and a 36% decrease in maximal rate of relaxation compared to wild-type cells
• following transverse aortic banding, decreased cardiomyocyte contractility is partially restored but not to wild-type levels
abnormal cardiac muscle relaxation ( J:143577 )
• cardiomyocytes exhibit a 36% decrease in maximal rate of relaxation compared to wild-type cells
abnormal myocardial fiber physiology ( J:143577 )
• transient calcium ion decay in cardiomyocytes is increased 29% compared to in wild-type cells
• cardiomyocyte sarcoplasmic reticulum re-uptake of calcium ions is reduced 39% compared to in wild-type cells
• however, baseline calcium ion content is normal
increased response of heart to induced stress ( J:143577 )
• following transverse aortic banding, mice exhibit a 65% increase in heart weight compared to a 38% increase in similarly treated wild-type mice with increased ventricular cross-sectional area
• following transverse aortic banding, decreased cardiomyocyte contractility is partially restored but not to wild-type levels

muscle
decreased cardiac muscle contractility ( J:143577 )
• cardiomyocytes exhibit a 23% decrease in cell shortening, a 29% decrease in maximal rate of contraction, and a 36% decrease in maximal rate of relaxation compared to wild-type cells
• following transverse aortic banding, decreased cardiomyocyte contractility is partially restored but not to wild-type levels
abnormal cardiac muscle relaxation ( J:143577 )
• cardiomyocytes exhibit a 36% decrease in maximal rate of relaxation compared to wild-type cells

homeostasis/metabolism
increased response of heart to induced stress ( J:143577 )
• following transverse aortic banding, mice exhibit a 65% increase in heart weight compared to a 38% increase in similarly treated wild-type mice with increased ventricular cross-sectional area
• following transverse aortic banding, decreased cardiomyocyte contractility is partially restored but not to wild-type levels




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory