Phenotypes associated with this allele

• Allele Symbol: Apod^tm1Dsan
• Allele Name: targeted mutation 1, Diego Sanchez
• Allele ID: MGI:3829240
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apod^tm1Dsan/Apod^tm1Dsan	either: B6.129X1-Apod^tm1Dsan or C.129X1-Apod^tm1Dsan	MGI:3829247

Genotype
MGI:3829247

hm1

• Allelic Composition: Apod^tm1Dsan/Apod^tm1Dsan
• Genetic Background: either: B6.129X1-Apod^tm1Dsan or C.129X1-Apod^tm1Dsan

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:143809 )

• following paraquat treatment both median and maximal life spans are reduced compared to similarly treated wild type mice

behavior/neurological

abnormal motor learning ( J:143809 )

• decreased improvement in rotarod performance over consecutive trials

abnormal spatial learning ( J:143809 )

• none of the mice are able to meet the learning criteria in a 70 day test period with a spatial version of the Barnes maze

abnormal spatial reference memory ( J:143809 )

• none of the mice are able to meet the learning criteria in a 70 day test period with a spatial version of the Barnes maze

decreased vertical activity ( J:143809 )

decreased locomotor activity ( J:143809 )

homeostasis/metabolism

abnormal lipid homeostasis ( J:143809 )

• increase in levels of lipid peroxides in the brain but not in the lung

• following treatment with paraquat (a reactive oxygen species generator) lipid peroxidation is increased to a greater extent compared to similarly treated wild type mice

increased susceptibility to xenobiotic induced morbidity/mortality ( J:143809 )

• following paraquat treatment both median and maximal life spans are reduced compared to similarly treated wild type mice

increased physiological sensitivity to xenobiotic ( J:143809 )

• following treatment with paraquat (a reactive oxygen species generator) lipid peroxidation is increased to a greater extent compared to similarly treated wild type mice

nervous system

abnormal nervous system physiology ( J:143809 )

• increase in levels of lipid peroxides in the brain