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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis
transgene insertion 1, Yuji Mishina
MGI:3829221
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Isl1tm1(cre)Sev/Isl1+
Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis/0 		involves: 129S7/SvEvBrd MGI:5444492
cn2
 		Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis/0
Tg(Tek-cre)1Ywa/0 		involves: 129S7/SvEvBrd * C57BL/6 * SJL MGI:5444494
cn3
 		Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis/0
Tg(Col1a1-cre/Esr1*)1Mis/0 		Not Specified MGI:3829250


Genotype
MGI:5444492
cn1
Allelic
Composition		 Isl1tm1(cre)Sev/Isl1+
Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis/0
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Sev mutation (1 available); any Isl1 mutation (33 available)
Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
atrioventricular septal defect ( J:189007 )
• membranous defect




Genotype
MGI:5444494
cn2
Allelic
Composition		 Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis/0
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis mutation (1 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
atrioventricular septal defect ( J:189007 )
• membranous defect




Genotype
MGI:3829250
cn3
Allelic
Composition		 Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis/0
Tg(Col1a1-cre/Esr1*)1Mis/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis mutation (1 available)
Tg(Col1a1-cre/Esr1*)1Mis mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
thin neurocranium ( J:143588 )
• at E18.5, tamoxifen-treated mice exhibit moderately thinner calvariae than wild-type mice
decreased bone mass ( J:143588 )
• at E18.5, tamoxifen-treated mice exhibit a moderately thinner calvariae than in wild-type mice

craniofacial
thin neurocranium ( J:143588 )
• at E18.5, tamoxifen-treated mice exhibit moderately thinner calvariae than wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory