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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sall2tm1Jkoh
targeted mutation 1, Jurgen Kohlhase
MGI:3828110
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sall2tm1Jkoh/Sall2tm1Jkoh involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3828120
hm2
 		Sall2tm1Jkoh/Sall2tm1Jkoh involves: 129S1/Sv * 129X1/SvJ MGI:3828119
hm3
 		Sall2tm1Jkoh/Sall2tm1Jkoh involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3828116
hm4
 		Sall2tm1Jkoh/Sall2tm1Jkoh involves: 129S1/Sv * 129X1/SvJ * DBA/2 MGI:3828124
hm5
 		Sall2tm1Jkoh/Sall2tm1Jkoh involves: 129S1/Sv * 129X1/SvJ * NZW MGI:3828121
cx6
 		Sall2tm1Jkoh/Sall2+
Sall4Gt(W097E01)Flo/Sall4+ 		involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ MGI:3828135
cx7
 		Sall2tm1Jkoh/Sall2tm1Jkoh
Sall4Gt(W097E01)Flo/Sall4+ 		involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J MGI:3828134


Genotype
MGI:3828120
hm1
Allelic
Composition		 Sall2tm1Jkoh/Sall2tm1Jkoh
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall2tm1Jkoh mutation (0 available); any Sall2 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
open neural tube ( J:143350 )
• Background Sensitivity: in some mice on a mixed 129 and CD-1 background neural tube defects are seen unlike in mice on a mixed 129 and C57BL/6 background

embryo
open neural tube ( J:143350 )
• Background Sensitivity: in some mice on a mixed 129 and CD-1 background neural tube defects are seen unlike in mice on a mixed 129 and C57BL/6 background

mortality/aging




Genotype
MGI:3828119
hm2
Allelic
Composition		 Sall2tm1Jkoh/Sall2tm1Jkoh
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall2tm1Jkoh mutation (0 available); any Sall2 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
open neural tube ( J:143350 )
• in some mice on a 129 background at E9.5 the neural folds remain unfused unlike in mice on a mixed 129 and C57BL/6 background
exencephaly ( J:143350 )
• seen in some mice at E11.5

embryo
open neural tube ( J:143350 )
• in some mice on a 129 background at E9.5 the neural folds remain unfused unlike in mice on a mixed 129 and C57BL/6 background

mortality/aging




Genotype
MGI:3828116
hm3
Allelic
Composition		 Sall2tm1Jkoh/Sall2tm1Jkoh
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall2tm1Jkoh mutation (0 available); any Sall2 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:143350 )
N
• Background Sensitivity: no neural tube defects are detected in mice on a mixed 129 and C57BL/6 background unlike in mice on a 129 background




Genotype
MGI:3828124
hm4
Allelic
Composition		 Sall2tm1Jkoh/Sall2tm1Jkoh
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall2tm1Jkoh mutation (0 available); any Sall2 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:143350 )
N
• Background Sensitivity: no neural tube defects are detected in mice on a mixed 129 and DBA/2 background unlike in mice on a 129 background




Genotype
MGI:3828121
hm5
Allelic
Composition		 Sall2tm1Jkoh/Sall2tm1Jkoh
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * NZW
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall2tm1Jkoh mutation (0 available); any Sall2 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
open neural tube ( J:143350 )
• Background Sensitivity: in some mice on a mixed 129 and NZW background neural tube defects are seen unlike in mice on a mixed 129 and C57BL/6 background

embryo
open neural tube ( J:143350 )
• Background Sensitivity: in some mice on a mixed 129 and NZW background neural tube defects are seen unlike in mice on a mixed 129 and C57BL/6 background

mortality/aging




Genotype
MGI:3828135
cx6
Allelic
Composition		 Sall2tm1Jkoh/Sall2+
Sall4Gt(W097E01)Flo/Sall4+
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall2tm1Jkoh mutation (0 available); any Sall2 mutation (51 available)
Sall4Gt(W097E01)Flo mutation (0 available); any Sall4 mutation (144 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
open neural tube ( J:143350 )
• partial penetrance of neural tube defects

embryo
open neural tube ( J:143350 )
• partial penetrance of neural tube defects

mortality/aging




Genotype
MGI:3828134
cx7
Allelic
Composition		 Sall2tm1Jkoh/Sall2tm1Jkoh
Sall4Gt(W097E01)Flo/Sall4+
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall2tm1Jkoh mutation (0 available); any Sall2 mutation (51 available)
Sall4Gt(W097E01)Flo mutation (0 available); any Sall4 mutation (144 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased embryonic neuroepithelium apoptosis ( J:143350 )
• increase in the number of apoptotic cells at the 9 to 13 somite stage
incomplete rostral neuropore closure ( J:143350 )
• full penetrance of neural tube defects
• at E9.5 the forebrain and midbrain neural folds are not fused

embryo
abnormal neural fold elevation formation ( J:143350 )
• at the 11 somite stage elevation of the neural folds in the cephalic region is reduced and distance between the tips is increased compared to controls
• at the 13 somite stage bending of the neural folds is similar to the 11 somite stage and the tips are far apart
incomplete rostral neuropore closure ( J:143350 )
• full penetrance of neural tube defects
• at E9.5 the forebrain and midbrain neural folds are not fused

mortality/aging

cellular
increased embryonic neuroepithelium apoptosis ( J:143350 )
• increase in the number of apoptotic cells at the 9 to 13 somite stage




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory