Phenotypes associated with this allele

• Allele Symbol: Sucnr1^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:3828087
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sucnr1^tm1Dgen/Sucnr1^tm1Dgen	B6.129P2-Sucnr1^tm1Dgen	MGI:3828096

Genotype
MGI:3828096

hm1

• Allelic Composition: Sucnr1^tm1Dgen/Sucnr1^tm1Dgen
• Genetic Background: B6.129P2-Sucnr1^tm1Dgen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell activation ( J:143337 )

• unlike in wild-type cells, treatment with succinate does not increase antigen-stimulated T cell activation as determined by IL2 production

decreased T cell proliferation ( J:143337 )

• the proliferation of tetanus toxoid-reactive cells from lymph nodes is reduced compared to proliferation of similarly treated wild-type cells

• tetanus toxoid-recall response after antigen immunization is impaired compared to in wild-type mice

• however, proliferation in response to treatment with phytohemagglutinin is normal

abnormal dendritic cell physiology ( J:143337 )

• fewer tetnus toxoid-stimulated dendritic cells migrate to lymph nodes compared to in similarly treated wild-type mice

• however, the number of dendritic cells in unstimulated lymph nodes is normal

abnormal Langerhans cell physiology ( J:143337 )

• fewer antigen-stimulated Langerhans cells drain to lymph nodes compared to in wild-type mice

abnormal interleukin-2 secretion ( J:143337 )

• unlike in wild-type cells, treatment with succinate does not increase IL2 production

increased length of allograft survival ( J:143337 )

• skin grafts transplanted onto wild-type mice exhibit longer survival time compared to corresponding allografts from wild-type tissue

hematopoietic system

abnormal T cell activation ( J:143337 )

• unlike in wild-type cells, treatment with succinate does not increase antigen-stimulated T cell activation as determined by IL2 production

decreased T cell proliferation ( J:143337 )

• the proliferation of tetanus toxoid-reactive cells from lymph nodes is reduced compared to proliferation of similarly treated wild-type cells

• tetanus toxoid-recall response after antigen immunization is impaired compared to in wild-type mice

• however, proliferation in response to treatment with phytohemagglutinin is normal

cellular

decreased T cell proliferation ( J:143337 )

• the proliferation of tetanus toxoid-reactive cells from lymph nodes is reduced compared to proliferation of similarly treated wild-type cells

• tetanus toxoid-recall response after antigen immunization is impaired compared to in wild-type mice

• however, proliferation in response to treatment with phytohemagglutinin is normal