Phenotypes associated with this allele

• Allele Symbol: Rrad^tm1Yec
• Allele Name: targeted mutation 1, Yuqing E Chen
• Allele ID: MGI:3827009
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rrad^tm1Yec/Rrad^tm1Yec	B6.129X1-Rrad^tm1Yec	MGI:3827010

Genotype
MGI:3827010

hm1

• Allelic Composition: Rrad^tm1Yec/Rrad^tm1Yec
• Genetic Background: B6.129X1-Rrad^tm1Yec

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:143140 )

N • normal heart weight and body weight

N • basal left ventricle contractility is normal

N • diastolic function is normal

increased heart weight ( J:143140 )

• significantly increased heart weight to body weight ratio 14 days after transverse aortic constriction as compared to controls

abnormal cardiac muscle contractility ( J:143140 )

• left ventricular contractility is stimulated to a lesser degree than controls by higher doses of dobutamine

muscle

abnormal cardiac muscle contractility ( J:143140 )

• left ventricular contractility is stimulated to a lesser degree than controls by higher doses of dobutamine

growth/size/body

increased heart weight ( J:143140 )

• significantly increased heart weight to body weight ratio 14 days after transverse aortic constriction as compared to controls