Analysis Tools
mortality/aging
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• most die between E10.5 and E12.5 with few surviving to die by E14.5
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Allele Symbol Allele Name Allele ID |
Hccstm1Tcc targeted mutation 1, Timothy C Cox MGI:3826866 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most die between E10.5 and E12.5 with few surviving to die by E14.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most die between E10.5 and E12.5 with few surviving to die by E14.5
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• at E13.5, glycogen storage in embryonic hearts is decreased compared to in wild-type mice
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• at E13.5, the degree of cardiomyocyte differentiation towards the ventricular lumen is lower than in wild-type mice
• at E13.5, cardiomyocytes have less mature sarcomeres with shorter, randomly arranged muscle fibrils unlike in wild-type mice
• however, mice exhibit normal cardiac morphology at E10.5 and E12.5
• at E13.5, cardiomyocytes accumulate a fine granular material unlike in wild-type cells
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• at E13.5, a subset of cardiomyocytes contain irregular mitochondria
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• at E11.5, proliferation of cardiomyocytes is decreased 45% compared to in wild-type mice
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• at E13.5, a subset of cardiomyocytes contain irregular mitochondria
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• at E11.5, proliferation of cardiomyocytes is decreased 45% compared to in wild-type mice
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• at E12.5 and E14.5, respiratory chain complex III activity in cardiomyocytes is 10% of normal
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• at E13.5, glycogen storage in embryonic hearts is decreased compared to in wild-type mice
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• at E13.5, glycogen storage in embryonic hearts is decreased compared to in wild-type mice
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• at E11.5, proliferation of cardiomyocytes is decreased 45% compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 13% of mice die between 9 and 15 months of age with varying degrees of dilated cardiomyopathy
• however, mice exhibit no embryonic lethality
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• at 8 weeks, pale and granulated cells resembling degenerating cardiomyocytes are found in the ventricular myocardium unlike in wild-type mice
• at 1 year, severely affected mice exhibit hypertrophic cardiocyocytes
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• at E13.5, a subset of cardiomyocytes contain irregular mitochondria
• however, no other cardiac abnormalities are observed at E13.5
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• in severely affected mice at 1 year
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• in severely affected mice at 1 year
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• in severely affected mice at 1 year
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• in mice with hypertrophic cardiomyocytes at 1 year
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• in severely affected mice at 1 year
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• at 1 year, mice with dilated cardiomyopathy exhibit increased interstitial fibrosis compared to mice that develop a hypertrophic cardiomyocyte-like phenotype
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• in severely affected mice at 1 year
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• at 1 year, 40% of mice exhibit pathologies of the cardiac conduction system including first degree atrioventricular (AV) block or intermittent second degree AV block type II
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• at 1 year, 40% of mice exhibit pathologies of the cardiac conduction system including sinus bradycardia
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• at 1 year, 40% of mice exhibit pathologies of the cardiac conduction system including transient bundle branch block
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• respiratory chain complex III activity in cardiomyocytes is reduced 43% at E12.5 and 56% at E14.5 compared to in wild-type cells
• however, cardiomyocytes is reduced at 8 weeks is normal
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• at E13.5, a subset of cardiomyocytes contain irregular mitochondria
• however, no other cardiac abnormalities are observed at E13.5
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• at 1 year, mice with dilated cardiomyopathy exhibit increased interstitial fibrosis compared to mice that develop a hypertrophic cardiomyocyte-like phenotype
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• respiratory chain complex III activity in cardiomyocytes is reduced 43% at E12.5 and 56% at E14.5 compared to in wild-type cells
• however, cardiomyocytes is reduced at 8 weeks is normal
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• in severely affected mice at 1 year
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• at 8 weeks, pale and granulated cells resembling degenerating cardiomyocytes are found in the ventricular myocardium unlike in wild-type mice
• at 1 year, severely affected mice exhibit hypertrophic cardiocyocytes
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• in severely affected mice at 1 year
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• in severely affected mice at 1 year
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E12.5, the relative volume of abnormal heart tissue begins to decline to 42% in ventricles and 47% in atria and is further reduced at E16.5 to 18% in ventricles and 19% in the atria then 10% in ventricles and 17% in the atria prior to birth
• at E12.5 and E13.5, cardiomyocytes appear small and round compared to wild-type cells
• however, the absolute volume of heart tissue before birth is unchanged
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• cardiomyocytes appear smaller at E12.5 and E13.5
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• while the number of affected cardiomyocytes decreases proliferation of normal cardiomyocytes increases in a compensatory manner
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• while the number of affected cardiomyocytes decreases proliferation of normal cardiomyocytes increases in a compensatory manner
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• while the number of affected cardiomyocytes decreases proliferation of normal cardiomyocytes increases in a compensatory manner
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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