Analysis Tools
skeleton
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• in vitro generation of functional osteoclasts from mutant bone marrow is about 50% greater than controls
• this was also observed when spleen cells are used as a source of osteoclastic precursors
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• mice showed reduced bone formation rate (BFR) in the 10-week-old females and 16-week old males
• is associated with a 54% reduction in mineralizing surface in 10-week-old females and a 33% reduction in mineral apposition rate in the 16-week-old males
• static markers of bone formation such as osteoblast number show no significant changes in male or female mice, suggesting that the reduced bone formation results from a reduction in osteoblast activity per cell
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• osteoclast number is increased in the tibia of male mice at 10 weeks of age, and female mice at 16 weeks of age
• there is increase in the number of TRAP-stained osteoclasts at the growth plate region and lining the trabecular bone surfaces in representative tibial sections of 16-week-old female mice
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short femur
(
J:143122
)
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• femur length is reduced in mice at six weeks of age but is normalized at 10 weeks of age
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• growth plate width in femurs is smaller in males at 6 weeks of age
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• lower tibial trabecular bone volume, decreased trabecular thickness, and decreased trabecular number are indicative of mild osteopenia in male mice
• this osteopenia results from an increase in osteoclast numbers
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• lower tibial trabecular bone volume, decreased trabecular thickness, and decreased trabecular number are all observed in the proximal tibia of male mice at 10 weeks of age
• while trabecular thickness normalizes by 16 weeks of age, the other parameters are still significantly lower in male mice at this age
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• lower tibial trabecular bone volume observed in the proximal tibia of male mice at 10 weeks of age
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• observed in the proximal tibia of male mice at 10 weeks of age
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• observed in the proximal tibia of male mice at 10 weeks of age
• while trabecular thickness normalizes by 16 weeks of age, the other parameters are still significantly lower in male mice at this age
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homeostasis/metabolism
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• PTH levels are depressed in female and male mice at 10 weeks of age, and in female mice at 16 weeks of age
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• serum calcium levels are 20-30% higher in 16 week old mice but are normal at 10 weeks of age
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hematopoietic system
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• in vitro generation of functional osteoclasts from mutant bone marrow is about 50% greater than controls
• this was also observed when spleen cells are used as a source of osteoclastic precursors
|
|
• osteoclast number is increased in the tibia of male mice at 10 weeks of age, and female mice at 16 weeks of age
• there is increase in the number of TRAP-stained osteoclasts at the growth plate region and lining the trabecular bone surfaces in representative tibial sections of 16-week-old female mice
|
immune system
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• in vitro generation of functional osteoclasts from mutant bone marrow is about 50% greater than controls
• this was also observed when spleen cells are used as a source of osteoclastic precursors
|
|
• osteoclast number is increased in the tibia of male mice at 10 weeks of age, and female mice at 16 weeks of age
• there is increase in the number of TRAP-stained osteoclasts at the growth plate region and lining the trabecular bone surfaces in representative tibial sections of 16-week-old female mice
|
limbs/digits/tail
short femur
(
J:143122
)
|
• femur length is reduced in mice at six weeks of age but is normalized at 10 weeks of age
|
cellular
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• in vitro generation of functional osteoclasts from mutant bone marrow is about 50% greater than controls
• this was also observed when spleen cells are used as a source of osteoclastic precursors
|
|
• mice showed reduced bone formation rate (BFR) in the 10-week-old females and 16-week old males
• is associated with a 54% reduction in mineralizing surface in 10-week-old females and a 33% reduction in mineral apposition rate in the 16-week-old males
• static markers of bone formation such as osteoblast number show no significant changes in male or female mice, suggesting that the reduced bone formation results from a reduction in osteoblast activity per cell
|
