Phenotypes associated with this allele

• Allele Symbol: Guca1b^tm1Amd
• Allele Name: targeted mutation 1, Alexander M Dizhoor
• Allele ID: MGI:3822772
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Guca1b^tm1Amd/Guca1b^tm1Amd	involves: 129 * C57BL/6	MGI:3822774

Genotype
MGI:3822774

hm1

• Allelic Composition: Guca1b^tm1Amd/Guca1b^tm1Amd
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:142552 )

N • photoreceptor morphology is normal

abnormal rod electrophysiology ( J:142552 )

• sensitivity to flash is increased compared to in wild-type mice

• after 100 ms during the rising phase, time to peak is delayed compared to in wild-type mice

• integration time is increased 1.5-fold compared to in wild-type mice

• recovery of bright flash response is slower than in wild-type mice

• when stimulated with steps of light, rods are 1.7-fold more sensitive and generated responses rise more gradually and peak later than in wild-type rods

• after light extinguishment, the circulating current recovery is delayed compared to in wild-type mice

• however, sodium/calcium and potassium exchange in rods is normal