Analysis Tools
nervous system
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• cultured DIV 5 cortical neurons show a significant reduction in the number of branches resulting in a decrease in dendritic tree complexity
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Allele Symbol Allele Name Allele ID |
Trp73tm1Mak targeted mutation 1, Tak Mak MGI:3822523 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• cultured DIV 5 cortical neurons show a significant reduction in the number of branches resulting in a decrease in dendritic tree complexity
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all mice die by 25 months
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• fewer than expected mice are born
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• 32% of mice develop lung adenocarcinoma
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• female mice have fewer gametes than wild-type mice
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• mice possess fewer primordial or early growing follicles compared to in wild-type mice
• however, the number of secondary follicles is normal
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• spindle abnormalities develop during meiosis
• however, oocytes progress through meiosis and arrest in metaphase II
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• spindle abnormalities develop during meiosis
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• during ovulation oocytes remain trapped in the luteinizing granulose cells unlike in wild-type mice
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• oocytes of mice induced to superovulate are trapped under bursa and do not progress towards the fallopian tubes
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• superovulated females release no oocytes unlike similarly treated wild-type mice
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• despite normal cyclicity and mating behavior, mice are infertile
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• despite mating behavior, mice are infertile
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• only 28% of in vitro fertilized oocytes from Trp73tm1Mak homozygous females form blastocysts compared to 75% of wild-type zygotes, and blastocysts that do form arrest in early cleavage
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• following treatment with DMBA mice develop tumors following a shorter latency than similarly treated wild-type mice
• however, sites of tumorigenesis following treatment with DMBA are the same as in similarly treated wild-type mice
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• 18% of mice develop lymphoma that infiltrate more than one organ compared to 6% of wild-type mice that develop non-infiltrating lymphoma
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• 14% of mice develop thymic lymphoma
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• 9% of mice develop colon carcinoma in situ
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• 32% of mice develop lung adenocarcinoma
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• female mice have fewer gametes than wild-type mice
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• nocodozole treated lung fibroblasts exhibit increased loss of euploidy compared to similarly treated wild-type cells
• however, nocodozole treated thymic cells are euploid
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• nocodozole treated mouse embryonic fibroblasts exhibit an increase in 8N cells compared to similarly treated wild-type cells
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• nocodozole treated mouse embryonic fibroblasts exhibit decreased mitotic arrest compared to similarly treated wild-type cells
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• only 28% of in vitro fertilized oocytes from Trp73tm1Mak homozygous females form blastocysts compared to 75% of wild-type zygotes, and blastocysts that do form arrest in early cleavage
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• at 10 weeks, the dentate gyrus is either completely missing or greatly reduced compared to in wild-type mice
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• following treatment with DMBA mice develop tumors following a shorter latency than similarly treated wild-type mice
• however, sites of tumorigenesis following treatment with DMBA are the same as in similarly treated wild-type mice
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• mice possess fewer primordial or early growing follicles compared to in wild-type mice
• however, the number of secondary follicles is normal
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• 14% of mice develop thymic lymphoma
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 10% of mice develop lymphoma that infiltrate more than one organ compared to 6% of wild-type mice that develop non-infiltrating lymphoma
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• 5% of mice develop thymic lymphoma
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• 5% of mice develop colon carcinoma in situ
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• 5% of mice develop lung adenocarcinoma
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• in 5% of mice
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• 5% of mice develop thymic lymphoma
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• 5% of mice develop lung adenocarcinoma
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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