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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kidins220+
wild type
MGI:3822479
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Kidins220tm1.1Mvc/Kidins220+ involves: 129S1/Sv * C57BL/6 MGI:4820798
cx2
 		Kidins220tm1.1Mvc/Kidins220+
Tg(Thy1-YFP)HJrs/0 		involves: 129S1/Sv * C57BL/6 * CBA MGI:4820799


Genotype
MGI:4820798
ht1
Allelic
Composition		 Kidins220tm1.1Mvc/Kidins220+
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kidins220tm1.1Mvc mutation (0 available); any Kidins220 mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dendrite morphology ( J:162839 )
• between 1 and 3 months, mice fail to exhibit an increase in dendritic complexity in the barrel somatosensory cortex unlike in wild-type mice
• at 3 months, mice exhibit decreased dendritic complexity in the dentate gyrus compared with wild-type mice




Genotype
MGI:4820799
cx2
Allelic
Composition		 Kidins220tm1.1Mvc/Kidins220+
Tg(Thy1-YFP)HJrs/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kidins220tm1.1Mvc mutation (0 available); any Kidins220 mutation (79 available)
Tg(Thy1-YFP)HJrs mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dendritic spine morphology ( J:162839 )
• in vivo, dendritic spines of pyramidal neurons are less stable than spines on wild-type cells
• however, spine formation rate is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory