Phenotypes associated with this allele

• Allele Symbol: Tg(Cyp21a1-Apoe)614Fet
• Allele Name: transgene insertion 614, Fayanne Thorngate
• Allele ID: MGI:3822327
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Apoe^tm1Unc/Apoe^tm1Unc Tg(Cyp21a1-Apoe)614Fet/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3822447
tg2	Tg(Cyp21a1-Apoe)614Fet/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3822446

Genotype
MGI:3822447

cx1

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Tg(Cyp21a1-Apoe)614Fet/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating cholesterol level ( J:130658 )

• total plasma cholesterol levels (TPC) are 132 +/- 12 mg/dl compared to normal range of control mice (70-100 mg/dl); levels of transgenic Apoe-null mice are almost normalized to levels of control littermates heterozygous for the mouse Apoe allele

abnormal circulating protein level ( J:130658 )

• mice have >3% (about 2.2 ug/ml) of wild-type plasma Apoe levels

cardiovascular system

decreased susceptibility to atherosclerosis ( J:130658 )

• mice show almost complete suppression of cholesteryl ester deposition (CE lesions) compared to nontransgenic Apoe-null littermates

Genotype
MGI:3822446

tg2

• Allelic Composition: Tg(Cyp21a1-Apoe)614Fet/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

homeostasis/metabolism

increased circulating cholesterol level ( J:130658 )

• total plasma cholesterol levels (TPC) are 843 +/- 137 mg/dl compared to normal range of control mice (70-100 mg/dl)