All Phenotypes Spint1<tm1Bug> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Spint1^tm1Bug
targeted mutation 1, Thomas H Bugge
MGI:3822295

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spint1^tm1Bug/Spint1^tm1Bug	involves: 129S6/SvEvTac	MGI:5440268
hm2	Spint1^tm1Bug/Spint1^tm1Bug	involves: 129S6/SvEvTac * NIH Black Swiss	MGI:3822302
cx3	Spint1^tm1Bug/Spint1^tm1Bug St14^tm1Bug/St14^tm1Bug	involves: 129P2/OlaHsd * 129S6/SvEvTac	MGI:5440269
cx4	Spint1^tm1Bug/Spint1^tm1Bug St14^tm1Bug/St14⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac	MGI:5440270
cx5	Spint1^tm1Bug/Spint1^tm1Bug St14^Gt(XM184)Byg/St14^Gt(XM184)Byg	involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss	MGI:3822303
cx6	Spint1^tm1Bug/Spint1^tm1Bug St14^tm1Bug/St14^tm1Bug	involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss	MGI:3822304
cx7	Prss8^fr/Prss8^fr Spint1^tm1Bug/Spint1^tm1Bug	involves: 129S6/SvEvTac * DBA	MGI:5440271
cx8	Prss8^fr/Prss8⁺ Spint1^tm1Bug/Spint1^tm1Bug	involves: 129S6/SvEvTac * DBA	MGI:5440272

Allelic Composition	Spint1^tm1Bug/Spint1^tm1Bug
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spint1^tm1Bug mutation (0 available); any Spint1 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:188121 )

• at E10.5

embryo

absent placental labyrinth ( J:188121 )

Allelic Composition	Spint1^tm1Bug/Spint1^tm1Bug
Genetic Background	involves: 129S6/SvEvTac * NIH Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spint1^tm1Bug mutation (0 available); any Spint1 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:142708 )

• normal development until E9.5 followed by severe growth retardation

• homozygous embryos all resorbed by E12.5

embryo

embryonic growth retardation ( J:142708 )

• after E9.5

absent placental labyrinth ( J:142708 )

abnormal trophoblast layer morphology ( J:142708 )

• chorionic trophoblast fails to grow in toward the spongial layer at E9.5

• chorionic trophoblast layer fails to continue normal differentiation after E9.0

• disorganized laminin deposition seen at E9.0

• chorionic trophoblasts present only as scattered clusters of cells at E9.5

growth/size/body

embryonic growth retardation ( J:142708 )

• after E9.5

Allelic Composition	Spint1^tm1Bug/Spint1^tm1Bug St14^tm1Bug/St14^tm1Bug
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spint1^tm1Bug mutation (0 available); any Spint1 mutation (26 available)
St14^tm1Bug mutation (0 available); any St14 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:188121 )

N	• survive past E10.5, unlike mice homozygous for Spint1^tm1Bug alone

embryo

embryo phenotype ( J:188121 )

N	• rescue of placental defects seen in mice homozygous for Spint1^tm1Bug alone

Allelic Composition	Spint1^tm1Bug/Spint1^tm1Bug St14^tm1Bug/St14⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:188121 )

• at E10.5

embryo

absent placental labyrinth ( J:188121 )

Allelic Composition	Spint1^tm1Bug/Spint1^tm1Bug St14^Gt(XM184)Byg/St14^Gt(XM184)Byg
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spint1^tm1Bug mutation (0 available); any Spint1 mutation (26 available)
St14^Gt(XM184)Byg mutation (0 available); any St14 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:142708 )

• double homozygotes born at near normal numbers

• die within the first day after birth

embryo

embryo phenotype ( J:142708 )

N	• placentas normal, including labyrinth layer • no growth retardation

behavior/neurological

absent gastric milk in neonates ( J:142708 )

• 75% of double homozygous mutant pups lack milk spots in the stomach

integument

absent vibrissae ( J:142708 )

• absence of erupted whiskers

abnormal epidermal layer morphology ( J:142708 )

• reddish, wrinkled, dry

abnormal epidermis stratum corneum morphology ( J:142708 )

abnormal corneocyte morphology ( J:142708 )

• tightly packed immature corneocytes

thin epidermis ( J:142708 )

dry skin ( J:142708 )

reddish skin ( J:142708 )

wrinkled skin ( J:142708 )

Allelic Composition	Spint1^tm1Bug/Spint1^tm1Bug St14^tm1Bug/St14^tm1Bug
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:142708 )

• double homozygotes born at near normal numbers

• die within the first day after birth

embryo

embryo phenotype ( J:142708 )

N	• placentas normal, including labyrinth layer • no growth retardation

behavior/neurological

absent gastric milk in neonates ( J:142708 )

• 75% of double homozygous mutant pups lack milk spots in the stomach

integument

absent vibrissae ( J:142708 )

• absence of erupted whiskers

abnormal epidermal layer morphology ( J:142708 )

• reddish, wrinkled, dry

abnormal epidermis stratum corneum morphology ( J:142708 )

abnormal corneocyte morphology ( J:142708 )

• tightly packed immature corneocytes

thin epidermis ( J:142708 )

dry skin ( J:142708 )

reddish skin ( J:142708 )

wrinkled skin ( J:142708 )

Allelic Composition	Prss8^fr/Prss8^fr Spint1^tm1Bug/Spint1^tm1Bug
Genetic Background	involves: 129S6/SvEvTac * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss8^fr mutation (13 available); any Prss8 mutation (24 available)
Spint1^tm1Bug mutation (0 available); any Spint1 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:188121 )

• many mice survive to term unlike mutant mice carrying at least 1 wild-type allele of Prss8

embryo

embryo phenotype ( J:188121 )

N	• no obvious developmental abnormalities are detected between E11.5 and E13.5 • complete rescue of placental labyrinth defects seen in mice homozygous for Spint1^tm1Bug alone

integument

abnormal coat appearance ( J:188121 )

• outwardly indistinguishable from littermates homozygous for Prss8^fr alone at up to 1 year of age

Allelic Composition	Prss8^fr/Prss8⁺ Spint1^tm1Bug/Spint1^tm1Bug
Genetic Background	involves: 129S6/SvEvTac * DBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:188121 )

embryo

spina bifida ( J:188121 )

abnormal placenta morphology ( J:188121 )

• placental differentiation defects

limbs/digits/tail

curly tail ( J:188121 )

nervous system

spina bifida ( J:188121 )

exencephaly ( J:188121 )

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