Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm3Hws mutation
(0 available);
any
Igh mutation
(43 available)
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immune system
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• the ratio of reading frame-1 usage of the DFL16.1 gene segment to reading frame-2 usage is reversed in the B cells of these mice
• mature B cells express heavy-chains with increased hydrophobicity compared to controls
• unique in-frame heavy chain transcripts from B cells at all stages of development have greater than 7 nucleotides lost at the 3' end
• unique in-frame heavy chain transcripts from mature B cells have decreased 5' nucleotide loss
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hematopoietic system
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• the ratio of reading frame-1 usage of the DFL16.1 gene segment to reading frame-2 usage is reversed in the B cells of these mice
• mature B cells express heavy-chains with increased hydrophobicity compared to controls
• unique in-frame heavy chain transcripts from B cells at all stages of development have greater than 7 nucleotides lost at the 3' end
• unique in-frame heavy chain transcripts from mature B cells have decreased 5' nucleotide loss
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm3Hws mutation
(0 available);
any
Igh mutation
(43 available)
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immune system
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• there is over a 40% decrease in the number of late pro-B cells (i.e. fraction D cells) compared to controls
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• numbers of CD19+ cells are reduced in the bone marrow and spleen by around 20% to 30%
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• there is about a 40% decrease in the number of immature B cells (ie. fraction E cells) found in the bone marrow
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• there is about a 30% decrease in the number of transitional T3(A) B cells (i.e. "anergic" B cells) found in the spleen
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• there is about a 40% decrease in the number of mature recirculating B cells found in the bone marrow
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• there is about a 40% decrease in the number of follicular B cells found in the spleen
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• spleen cellularity is reduced around 20% compared to controls
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• antigen specific IgG1 levels are reduced 6-fold compared to wild-type in response to immunization with a recombinant strain of Salmonella that elicits a T cell-dependent B cell response
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• antigen specific IgG2a levels are reduced 6-fold compared to wild-type in response to immunization with a recombinant strain of Salmonella that elicits a T cell-dependent B cell response
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• antigen specific IgG2a levels are reduced 34-fold compared to wild-type in response to immunization with a recombinant strain of Salmonella that elicits a T cell-dependent B cell response
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• antigen specific IgM levels are one-third of that observed in wild-type controls seven days after immunization with the T cell-independent antigen DEX
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• antigen specific IgM levels increase 4-fold over wild-type in response to immunization with a recombinant strain of Salmonella that elicits a T cell-dependent B cell response
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hematopoietic system
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• there is over a 40% decrease in the number of late pro-B cells (i.e. fraction D cells) compared to controls
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• there is about a 25% reduction in the number of cells found in the bone marrow
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• numbers of CD19+ cells are reduced in the bone marrow and spleen by around 20% to 30%
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• there is about a 40% decrease in the number of immature B cells (ie. fraction E cells) found in the bone marrow
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• there is about a 30% decrease in the number of transitional T3(A) B cells (i.e. "anergic" B cells) found in the spleen
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• there is about a 40% decrease in the number of mature recirculating B cells found in the bone marrow
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• there is about a 40% decrease in the number of follicular B cells found in the spleen
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• spleen cellularity is reduced around 20% compared to controls
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• antigen specific IgG1 levels are reduced 6-fold compared to wild-type in response to immunization with a recombinant strain of Salmonella that elicits a T cell-dependent B cell response
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• antigen specific IgG2a levels are reduced 6-fold compared to wild-type in response to immunization with a recombinant strain of Salmonella that elicits a T cell-dependent B cell response
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• antigen specific IgG2a levels are reduced 34-fold compared to wild-type in response to immunization with a recombinant strain of Salmonella that elicits a T cell-dependent B cell response
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• antigen specific IgM levels are one-third of that observed in wild-type controls seven days after immunization with the T cell-independent antigen DEX
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• antigen specific IgM levels increase 4-fold over wild-type in response to immunization with a recombinant strain of Salmonella that elicits a T cell-dependent B cell response
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Analysis Tools