All Phenotypes Mir133a-2<tm1.1Eno> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mir133a-2^tm1.1Eno
targeted mutation 1.1, Eric N Olson
MGI:3822158

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir133a-2^tm1.1Eno/Mir133a-2^tm1.1Eno	involves: 129S/SvEv * C57BL/6 * SJL	MGI:3822177
cx2	Mir133a-1^tm1.1Eno/Mir133a-1^tm1.1Eno Mir133a-2^tm1.1Eno/Mir133a-2^tm1.1Eno	involves: 129S/SvEv * C57BL/6 * SJL	MGI:3822175

Allelic Composition	Mir133a-2^tm1.1Eno/Mir133a-2^tm1.1Eno
Genetic Background	involves: 129S/SvEv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir133a-2^tm1.1Eno mutation (0 available); any Mir133a-2 mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:142220 )

• mice are viable

Allelic Composition	Mir133a-1^tm1.1Eno/Mir133a-1^tm1.1Eno Mir133a-2^tm1.1Eno/Mir133a-2^tm1.1Eno
Genetic Background	involves: 129S/SvEv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir133a-1^tm1.1Eno mutation (0 available); any Mir133a-1 mutation (2 available)
Mir133a-2^tm1.1Eno mutation (0 available); any Mir133a-2 mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:142220 )

• underrepresented at birth, and 50% of the remaining mice die within the first postnatal day

• ~24% of total dKO mice survived to adulthood

prenatal lethality, incomplete penetrance ( J:142220 )

• analysis of offspring from timed matings of heterozygous mutant mice revealed dKO mutant embryos between embryonic day 10.5 (E10.5) and E17.5 at a frequency slightly less than Mendelian with occasional dead dKO embryos

cardiovascular system

abnormal heart morphology ( J:142220 )

abnormal myocardial fiber morphology ( J:142220 )

dilated heart atrium ( J:142220 )

enlarged heart ( J:142220 )

abnormal heart ventricle morphology ( J:142220 )

abnormal interventricular septum morphology ( J:142220 )

abnormal heart right ventricle morphology ( J:142220 )

thin ventricular wall ( J:142220 )

cardiac fibrosis ( J:142220 )

abnormal cardiovascular system physiology ( J:142220 )

dilated cardiomyopathy ( J:142220 )

decreased cardiac muscle contractility ( J:142220 )

decreased ventricle muscle contractility ( J:142220 )

increased cardiomyocyte apoptosis ( J:142220 )

muscle

abnormal myocardial fiber morphology ( J:142220 )

dilated cardiomyopathy ( J:142220 )

decreased cardiac muscle contractility ( J:142220 )

decreased ventricle muscle contractility ( J:142220 )

increased cardiomyocyte apoptosis ( J:142220 )

cellular

increased cardiomyocyte apoptosis ( J:142220 )

growth/size/body

enlarged heart ( J:142220 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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