|
Allele Symbol Allele Name Allele ID |
Mir133a-2tm1Eno targeted mutation 1, Eric N Olson MGI:3822156 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• in mice that die in the first day and in all mice by 4 months
• pronounced sarcomere fragmentation and disorganization
• disrupted Z discs
• vacuolation of mitochondria and loss of cristae
• 2.5 fold increase in cardiomyocyte proliferation
|
|
• in mice that die in the first day
|
|
• ventricular septum is fenestrated and thinned about 25%
• hypocellularity of the wall of the ventricular septum near the apex of the heart in a subset of mutants at P1
|
|
• all dKO mice that died at P1 exhibited large VSDs near the apex
• similar to, although more severe than, the trabecular (muscular) VSD in humans
• also observed VSDs near the atrioventricular valve at P1
|
|
• free wall of the right ventricle is thinned to half the thickness of controls at E15.5
|
|
• free wall of the right ventricle at E15.5
• free wall of both ventricles at E17.5 and in mice that survive to 5-6 months
|
|
• at E15.5 and at E17.5
|
|
• extensive by 4 months of age but no cardiomyocyte hypertrophy
|
|
• at 5-6 months of age
• about half of 5-6 month old mice experience sudden death
|
|
• at systole by 2-4 months of age
• impaired fractional shortening of the heart
|
|
• increased left ventricular inner diameter at systole
|
|
• at day 1
• at the apex and base of the interventricular septum
• near the atrioventricular valves
|
|
• in mice that die in the first day and in all mice by 4 months
• pronounced sarcomere fragmentation and disorganization
• disrupted Z discs
• vacuolation of mitochondria and loss of cristae
• 2.5 fold increase in cardiomyocyte proliferation
|
|
• at 5-6 months of age
• about half of 5-6 month old mice experience sudden death
|
|
• at systole by 2-4 months of age
• impaired fractional shortening of the heart
|
|
• increased left ventricular inner diameter at systole
|
|
• at day 1
• at the apex and base of the interventricular septum
• near the atrioventricular valves
|
|
• underrepresented at birth, and 50% of the remaining mice die within the first postnatal day
• ~24% of total dKO mice survived to adulthood
|
|
• analysis of offspring from timed matings of heterozygous mutant mice revealed dKO mutant embryos between embryonic day 10.5 (E10.5) and E17.5 at a frequency slightly less than Mendelian with occasional dead dKO embryos
|
|
• blood filled and containing thrombi in mice that die in the first day
• atrial thrombi in mice that survive to 5-6 months
|
|
• at day 1
• at the apex and base of the interventricular septum
• near the atrioventricular valves
|
|
• in mice that die in the first day
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/23/2024 MGI 6.23 |
|
|
|
||
Analysis Tools