Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flrt3tm2Kln mutation
(0 available);
any
Flrt3 mutation
(44 available)
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mortality/aging
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• by P15 less than 3% of mice are viable
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flrt3tm2Kln mutation
(0 available);
any
Flrt3 mutation
(44 available)
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mortality/aging
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• by P15 less than 3% of mice are viable
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• fewer than expected mice are present at E12.5 to E13.5
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embryo
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• at E8.5 to E9.5, some embryos develop outside of the yolk sac
• during head fold development, the neuroectoderm replaces the definitive ectoderm and the anterior portion of the embryo breaks through the yolk sac unlike in wild-type mice
• however, embryonic patterning and cell proliferation, apoptosis and migration during early development are normal
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• in some mice at E8.5 to E9.5
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• at E8.5 to E9.5, some mice exhibit asymmetric head folds while others exhibit heads that develop outside of the yolk sac
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• some mice exhibit an anterior neural tube closure defect
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• in some mice at E8.5 to E9.5
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• 79% of mice exhibit a rupture in the basement membrane that results in holes in the anterior visceral endoderm
• disruption of the basement membrane precedes disruption in the anterior visceral endoderm and induces epithelial-mesenchymal transition unlike in wild-type mice
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nervous system
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• at E8.5 to E9.5, some mice exhibit asymmetric head folds while others exhibit heads that develop outside of the yolk sac
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• some mice exhibit an anterior neural tube closure defect
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cardiovascular system
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• in some mice at E8.5 to E9.5
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growth/size/body
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• some mice exhibit failure of the ventral body to close
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cellular
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• 79% of mice exhibit a rupture in the basement membrane that results in holes in the anterior visceral endoderm
• disruption of the basement membrane precedes disruption in the anterior visceral endoderm and induces epithelial-mesenchymal transition unlike in wild-type mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flrt3tm2Kln mutation
(0 available);
any
Flrt3 mutation
(44 available)
|
|
|
mortality/aging
|
• by P15 less than 3% of mice are viable
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flrt3tm1Kln mutation
(0 available);
any
Flrt3 mutation
(44 available)
Flrt3tm2Kln mutation
(0 available);
any
Flrt3 mutation
(44 available)
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embryo
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• 19 of 24 mice exhibit a rupture in the basement membrane that results in holes in the anterior visceral endoderm
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cellular
|
• 19 of 24 mice exhibit a rupture in the basement membrane that results in holes in the anterior visceral endoderm
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flrt3tm2Kln mutation
(0 available);
any
Flrt3 mutation
(44 available)
Flrt3tm3Kln mutation
(0 available);
any
Flrt3 mutation
(44 available)
Tg(Pgk1-cre)1Lni mutation
(1 available)
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