Phenotypes associated with this allele

• Allele Symbol: Shmt1^tm1Stov
• Allele Name: targeted mutation 1, Patrick J Stover
• Allele ID: MGI:3821629
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Shmt1^tm1Stov/Shmt1^tm1Stov	involves: 129S7/SvEvBrd * C57BL/6	MGI:3821698
ht2	Shmt1^tm1Stov/Shmt1^+	involves: 129S7/SvEvBrd * C57BL/6	MGI:3821699

Genotype
MGI:3821698

hm1

• Allelic Composition: Shmt1^tm1Stov/Shmt1^tm1Stov
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating cystathionine level ( J:141998 )

• significant decrease in cystathionine levels in mice on a folate/choline deficient diet compared to wild-type controls

• decrease in cystathionine level is less than that in heterozygous mice

increased circulating cysteine level ( J:141998 )

• increased plasma cysteine levels in mice on a folate/choline deficient diet compared to wild-type controls

Genotype
MGI:3821699

ht2

• Allelic Composition: Shmt1^tm1Stov/Shmt1⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

homeostasis/metabolism

decreased circulating cystathionine level ( J:141998 )

• significant decrease in cystathionine levels in mice on a folate/choline deficient diet compared to wild-type controls

• decrease in cystathionine level is greater than that in homozygous mutant mice