All Phenotypes Gfi1b<tm1Tmo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gfi1b^tm1Tmo
targeted mutation 1, Tarik Moroy
MGI:3821577

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gfi1b^tm1Tmo/Gfi1b^tm1Tmo	B6.129-Gfi1b^tm1Tmo	MGI:3821578

Allelic Composition	Gfi1b^tm1Tmo/Gfi1b^tm1Tmo
Genetic Background	B6.129-Gfi1b^tm1Tmo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1b^tm1Tmo mutation (1 available); any Gfi1b mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:141749 )

• homozygotes are embryonic lethal with development stopping at E15

cardiovascular system

internal hemorrhage ( J:141749 )

• E15 embryos are pale and have internal hemorrhages

hematopoietic system

abnormal erythropoiesis ( J:141749 )

• only a small fraction of the cells fully differentiate into erythrocytes in the fetal liver of E15 embryos with an accumulation occurring of Ter119^int/CD71^int immature cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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