Phenotypes associated with this allele

• Allele Symbol: Ahr^tm4.1Bra
• Allele Name: targeted mutation 4.1, Christopher A Bradfield
• Allele ID: MGI:3821486
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ahr^tm4.1Bra/Ahr^tm4.1Bra	involves: 129/Sv * C57BL/6	MGI:3821487

Genotype
MGI:3821487

hm1

• Allelic Composition: Ahr^tm4.1Bra/Ahr^tm4.1Bra
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:141978 )

• treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) fails to induce increased ethoxyresorufin O-deethylase activity

• no significant change in liver or thymus weight, no increase in liver lipid content, and no induction of cleft palate or hydroneohrosis following TCDD treatment

growth/size/body

enlarged heart ( J:141978 )

• 25% larger compared to littermate controls at 8 weeks of age

enlarged spleen ( J:141978 )

• 58% larger compared to littermate controls at 8 weeks of age

liver/biliary system

small liver ( J:141978 )

• 25% smaller compared to littermate controls at 8 weeks of age

microvesicular hepatic steatosis ( J:141978 )

• transient microvesicular steatosis from around P7 to P14

cardiovascular system

patent ductus venosus ( J:141978 )

enlarged heart ( J:141978 )

• 25% larger compared to littermate controls at 8 weeks of age

hematopoietic system

enlarged spleen ( J:141978 )

• 58% larger compared to littermate controls at 8 weeks of age

immune system

enlarged spleen ( J:141978 )

• 58% larger compared to littermate controls at 8 weeks of age

cellular

patent ductus venosus ( J:141978 )